Publications by authors named "Daniel F Wyss"

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WRN structural flexibility showcased through fragment-based lead discovery of inhibitors.
Rachel L Palte, Mihir Mandal, Justyna Sikorska, Artjohn B Villafania, Meredith M Rickard, Daniel F Wyss

Nat Commun· January 2026

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Recent developments in understanding RIG-I's activation and oligomerization.
Justyna Sikorska, Daniel F Wyss

Sci Prog· August 2024

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Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.
Justyna Sikorska, Yan Hou, Paul Chiurazzi, Tony Siu, Gretchen A Baltus, Daniel F Wyss

Nucleic Acids Res· September 2023

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Daniel F Wyss

J Med Chem· December 2022

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Wonsuk Chang, Michael D Altman, Charles A Lesburg, Samanthi A Perera, Jennifer A Piesvaux, Daniel F Wyss

J Med Chem· April 2022

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An orally available non-nucleotide STING agonist with antitumor activity.
Bo-Sheng Pan, Samanthi A Perera, Jennifer A Piesvaux, Jeremy P Presland, Gottfried K Schroeder, Daniel F Wyss

Science· August 2020

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NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.
Yan Hou, Todd Mayhood, Payal Sheth, Christopher M Tan, Marc Labroli, Daniel F Wyss

J Biomol Screen· July 2016

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NMR screening in fragment-based drug design: a practical guide.
Hai-Young Kim, Daniel F Wyss

Methods Mol Biol· September 2015

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Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
Daniel F Wyss, Yu-Sen Wang, Hugh L Eaton, Corey Strickland, Johannes H Voigt

Top Curr Chem· August 2012

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Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.
Xiaohua Huang, Gerald W Shipps, Cliff C Cheng, Peter Spacciapoli, Xingmin Zhang, Daniel F Wyss

ACS Med Chem Lett· August 2011

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Effective progression of nuclear magnetic resonance-detected fragment hits.
Hugh L Eaton, Daniel F Wyss

Methods Enzymol· June 2011

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Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase.
Cliff C Cheng, Xiaohua Huang, Gerald W Shipps, Yu-Sen Wang, Daniel F Wyss

ACS Med Chem Lett· December 2010

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Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Johannes Voigt, Corey Strickland, Daniel F Wyss

J Med Chem· February 2010

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Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Yu-Sen Wang, Corey Strickland, Johannes H Voigt, Matthew E Kennedy, Brian M Beyer, Daniel F Wyss

J Med Chem· February 2010

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Characterization of autocatalytic conversion of precursor BACE1 by heteronuclear NMR spectroscopy.
Yu-Sen Wang, Brian M Beyer, Mary M Senior, Daniel F Wyss

Biochemistry· December 2005

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Screening of protein kinases by ATP-STD NMR spectroscopy.
Mark A McCoy, Mary M Senior, Daniel F Wyss

J Am Chem Soc· June 2005

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Solution structure of the hypothetical protein SAV1595 from Staphylococcus aureus, a putative RNA binding protein.
Dingjiang Liu, Daniel F Wyss

J Biomol NMR· July 2004

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Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1.
Dingjiang Liu, Yu-Sen Wang, Jennifer J Gesell, Eileen Wilson, Brian M Beyer, Daniel F Wyss

J Biomol NMR· July 2004

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Competition STD NMR for the detection of high-affinity ligands and NMR-based screening.
Yu-Sen Wang, Dingjiang Liu, Daniel F Wyss

Magn Reson Chem· June 2004

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Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.
Daniel F Wyss, Ashok Arasappan, Mary M Senior, Yu-Sen Wang, Brian M Beyer

J Med Chem· May 2004

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Sequence-specific assignments of methyl groups in high-molecular weight proteins.
Daiwen Yang, Yu Zheng, Dingjiang Liu, Daniel F Wyss

J Am Chem Soc· March 2004

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Solution structure of the hypothetical protein YqgF from Escherichia coli reveals an RNAse H fold.
Dingjiang Liu, Yu-Sen Wang, Daniel F Wyss

J Biomol NMR· December 2003

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Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.
Dingjiang Liu, William T Windsor, Daniel F Wyss

Protein Sci· December 2003

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Structure-guided applications in drug discovery.
Daniel F Wyss

Drug Discov Today· October 2003

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Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation.
Mark A McCoy, Jennifer J Gesell, Mary M Senior, Daniel F Wyss

Proc Natl Acad Sci U S A· February 2003

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