Publications by authors named "Payal Sheth"

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Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.
James J Mignone, Elizabeth A Jurica, Deepa Rajasekaran, Jaclyn Robustelli, Courtney McCarthy, Payal Sheth

J Med Chem· October 2025

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The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors.
Ken Ellsworth, Peter Nizner, Anthony Ogawa, Alan Hruza, Lan Wei, Payal Sheth

ACS Pharmacol Transl Sci· September 2025

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Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.
Justyna Sikorska, Yan Hou, Paul Chiurazzi, Tony Siu, Gretchen A Baltus, Payal Sheth

Nucleic Acids Res· September 2023

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Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1.
Carl J Balibar, Daniel J Klein, Beata Zamlynny, Tracy L Diamond, Zhiyu Fang, Payal Sheth

Sci Transl Med· February 2023

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Payal Sheth

J Med Chem· December 2022

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Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α.
Paul Tawa, Lei Zhang, Essam Metwally, Yan Hou, Mark A McCoy, Payal Sheth

J Biol Chem· September 2022

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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.
Santhosh Satapati, Daniel P Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Payal R Sheth

SLAS Discov· January 2022

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Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats.
Payal A Sheth, Anil T Pawar, Chandrashekhar S Mote, Chandrakant More

J Ayurveda Integr Med· May 2021

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Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2.
Xiujuan Wen, Chang Liu, Lucien Ghislain, Kiersten Tovar, Vinit Shah, Payal R Sheth

Anal Chem· April 2021

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Mapping Lipogenic Flux: A Gold LDI-MS Approach for Imaging Neutral Lipid Kinetics.
Daniel P Downes, Wendy Zhong, Ji Zhang, Bingming Chen, Santhosh Satapati, Payal R Sheth

J Am Soc Mass Spectrom· December 2020

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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of H-Labeling of Small Molecules.
Daniel P Downes, Takhar Kasumov, Natalie A Daurio, Neil B Wood, Michael J Previs, Payal R Sheth

Metabolites· November 2020

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Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects.
Natalie A Daurio, Haihong Zhou, Ying Chen, Payal R Sheth, Jason E Imbriglio

ACS Chem Biol· October 2020

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.
Scott S Walker, Marc Labroli, Ronald E Painter, Judyann Wiltsie, Brad Sherborne, Payal Sheth

PLoS One· September 2017

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Jun Lu, Noel Byrne, John Wang, Gerard Bricogne, Frank K Brown, Payal Sheth

Nat Struct Mol Biol· July 2017

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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
Mihirbaran Mandal, Zheng Tan, Christina Madsen-Duggan, Alexei V Buevich, John P Caldwell, Payal Sheth

J Med Chem· May 2017

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Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.
Scott S Walker, David Degen, Elliott Nickbarg, Donna Carr, Aileen Soriano, Payal Sheth

ACS Chem Biol· May 2017

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Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.
Lorraine D Hernandez, Heather K Kroh, Edward Hsieh, Xiaoyu Yang, Maribel Beaumont, Payal R Sheth

J Mol Biol· April 2017

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Structural basis for selectivity and diversity in angiotensin II receptors.
Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L White, Payal Sheth

Nature· April 2017

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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.
Olga Berejnaia, Hao Wang, Marc Labroli, Christine Yang, Charles Gill, Payal R Sheth

Anal Biochem· February 2017

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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
Shu-Wei Yang, Jianping Pan, Christine Yang, Marc Labroli, Weidong Pan, Payal R Sheth

Bioorg Med Chem Lett· October 2016

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NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.
Yan Hou, Todd Mayhood, Payal Sheth, Christopher M Tan, Marc Labroli

J Biomol Screen· July 2016

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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.
Paul A Mann, Anna Müller, Kerstin A Wolff, Thierry Fischmann, Hao Wang, Payal R Sheth

PLoS Pathog· May 2016

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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.
Sang Ho Lee, Hao Wang, Marc Labroli, Sandra Koseoglu, Paul Zuck, Payal R Sheth

Sci Transl Med· March 2016

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Selective small-molecule inhibition of an RNA structural element.
John A Howe, Hao Wang, Thierry O Fischmann, Carl J Balibar, Li Xiao, Payal R Sheth

Nature· October 2015

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Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling.
Lorraine D Hernandez, Fred Racine, Li Xiao, Edward DiNunzio, Nichelle Hairston, Payal R Sheth

Antimicrob Agents Chemother· February 2015

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