Publications by authors named "Scott S Walker"

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Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition.
Morgan E Walker, Wei Zhu, Janine H Peterson, Hao Wang, Jon Patteson, Scott S Walker

Nat Commun· April 2025

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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat : From Screening Impurity to Efficacy.
Jason W Skudlarek, Andrew J Cooke, Helen J Mitchell, Kerim Babaoglu, Anthony W Shaw, Scott S Walker

J Med Chem· September 2024

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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Scott S Walker

Nat Microbiol· May 2024

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Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics.
Inga V Leus, Justyna Adamiak, Brinda Chandar, Vincent Bonifay, Shibin Zhao, Scott S Walker

Antimicrob Agents Chemother· February 2023

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Are outer-membrane targets the solution for MDR Gram-negative bacteria?
Scott S Walker, Todd A Black

Drug Discov Today· September 2021

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A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier.
Elizabeth M Hart, Angela M Mitchell, Anna Konovalova, Marcin Grabowicz, Jessica Sheng, Scott S Walker

Proc Natl Acad Sci U S A· October 2019

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Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins.
Anna Konovalova, Marcin Grabowicz, Carl J Balibar, Juliana C Malinverni, Ronald E Painter, Scott S Walker

Proc Natl Acad Sci U S A· July 2018

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Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.
Noreen F Rizvi, John A Howe, Ali Nahvi, Daniel J Klein, Thierry O Fischmann, Scott S Walker

ACS Chem Biol· March 2018

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.
Scott S Walker, Marc Labroli, Ronald E Painter, Judyann Wiltsie, Brad Sherborne

PLoS One· September 2017

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Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.
Scott S Walker, David Degen, Elliott Nickbarg, Donna Carr, Aileen Soriano

ACS Chem Biol· May 2017

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Selective small-molecule inhibition of an RNA structural element.
John A Howe, Hao Wang, Thierry O Fischmann, Carl J Balibar, Li Xiao, Scott S Walker

Nature· October 2015

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Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
Gang Zhou, Pauline C Ting, Grant Wishart, Nicolas Zorn, Robert G Aslanian, Scott S Walker

Bioorg Med Chem Lett· April 2014

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Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Pauline C Ting, Joe F Lee, Nicolas Zorn, Hyunjin M Kim, Robert G Aslanian, Scott S Walker

Bioorg Med Chem Lett· February 2013

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The optimization of pyridazinone series of glucan synthase inhibitors.
Rongze Kuang, Heping Wu, Pauline C Ting, Robert G Aslanian, Jianhua Cao, Scott S Walker

Bioorg Med Chem Lett· August 2012

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Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.
Andrew J Zych, Sang Q Lam, David M Jenkins, R Jason Herr, Pauline C Ting, Scott S Walker

Bioorg Med Chem Lett· July 2012

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Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.
Scott S Walker, Yiming Xu, Ilias Triantafyllou, Michelle F Waldman, Cara Mendrick

Antimicrob Agents Chemother· November 2011

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SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors.
Gang Zhou, Pauline C Ting, Robert Aslanian, Jianhua Cao, David W Kim, Scott S Walker

Bioorg Med Chem Lett· May 2011

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The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors.
Pauline C Ting, Rongze Kuang, Heping Wu, Robert G Aslanian, Jianhua Cao, Scott S Walker

Bioorg Med Chem Lett· March 2011

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Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation.
Samuel A Hasson, Robert Damoiseaux, Jenny D Glavin, Deepa V Dabir, Scott S Walker

Proc Natl Acad Sci U S A· May 2010

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New agents to treat life-threatening fungal infections.
Pauline C Ting, Scott S Walker

Curr Top Med Chem· June 2008

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Sphingolipid biosynthesis in pathogenic fungi: identification and characterization of the 3-ketosphinganine reductase activity of Candida albicans and Aspergillus fumigatus.
Michelle Fornarotto, Li Xiao, Yan Hou, Keith A Koch, Edcon Chang, Scott S Walker

Biochim Biophys Acta· January 2006

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Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.
Paul A Mann, Raulo M Parmegiani, Shui-Qing Wei, Cara A Mendrick, Xin Li, Scott S Walker

Antimicrob Agents Chemother· February 2003

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Genomics strategies for antifungal drug discovery--from gene discovery to compound screening.
Debra Aker Willins, Marco Kessler, Scott S Walker, Gregory R Reyes, Guillaume Cottarel

Curr Pharm Des· October 2002

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