Publications by authors named "Gillian Bates"

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Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice.
Jillian Belgrad, Ashley Summers, Christian Landles, Jonathan R Greene, Samuel Hildebrand, Gillian P Bates

bioRxiv· June 2025

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Somatic CAG-repeat expansion drives neuronal loss in Huntington's disease.
Gillian P Bates

Neuron· February 2025

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Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models.
Marina Sogorb-Gonzalez, Christian Landles, Nicholas S Caron, Anouk Stam, Georgina Osborne, Gillian P Bates

Brain· December 2024

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mA modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts.
Anika Pupak, Irene Rodríguez-Navarro, Kirupa Sathasivam, Ankita Singh, Amelie Essmann, Gillian P Bates

EMBO Rep· November 2024

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Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays.
Christian Landles, Georgina F Osborne, Jemima Phillips, Maria Canibano-Pico, Iulia M Nita, Gillian P Bates

Brain Commun· November 2024

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Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fasted .
Nikolaos Tataridas-Pallas, Yahyah Aman, Rhianna Williams, Hannah Chapman, Kevin J H Cheng, Gillian P Bates

iScience· June 2024

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A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Sarah G Aldous, Edward J Smith, Christian Landles, Georgina F Osborne, Maria Cañibano-Pico, Gillian P Bates

Brain· May 2024

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Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.
Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Gillian P Bates

Mol Med· April 2024

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Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.
Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Gillian P Bates

Mol Med· March 2024

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Translatable plasma and CSF biomarkers for use in mouse models of Huntington's disease.
Marie K Bondulich, Jemima Phillips, María Cañibano-Pico, Iulia M Nita, Lauren M Byrne, Gillian P Bates

Brain Commun· February 2024

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Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington's disease.
Ashwinee Manivannan, Lesley M Foley, T Kevin Hitchens, Ivan Rattray, Gillian P Bates

Neuroprotection· September 2023

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Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.
Edward J Smith, Kirupa Sathasivam, Christian Landles, Georgina F Osborne, Michael A Mason, Gillian P Bates

Brain Commun· January 2023

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Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.
Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer, Rebecca E Milton, Gillian P Bates

Brain· December 2022

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Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models.
Karlijne W Geijtenbeek, Jolien Janzen, Aleksandra E Bury, Alicia Sanz-Sanz, Ron A Hoebe, Gillian P Bates

PLoS One· December 2022

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Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.
Xiaofeng Gu, Jeffrey Richman, Peter Langfelder, Nan Wang, Shasha Zhang, Gillian P Bates

Neuron· April 2022

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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.
Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P Bates

Int J Mol Sci· August 2021

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FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Robert Goold, Joseph Hamilton, Thomas Menneteau, Michael Flower, Emma L Bunting, Gillian P Bates

Cell Rep· August 2021

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Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice.
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Gillian P Bates

Front Neurosci· June 2021

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Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery.
Edward J Smith, Pamela P Farshim, Rachel Flomen, Samuel T Jones, Sean J McAteer, Gillian P Bates

Brain Commun· May 2021

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Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.
Ya Zhou, Thomas R Peskett, Christian Landles, John B Warner, Kirupa Sathasivam, Gillian P Bates

Acta Neuropathol Commun· April 2021

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The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction.
Casandra Gomez-Paredes, Michael A Mason, Bridget A Taxy, Aikaterini S Papadopoulou, Paolo Paganetti, Gillian P Bates

Sci Rep· April 2021

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Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington's disease.
Marie Katrin Bondulich, Yilan Fan, Yeojin Song, Flaviano Giorgini, Gillian P Bates

Sci Rep· March 2021

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Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.
Anna Bobrowska, Gizem Donmez, Andreas Weiss, Leonard Guarente, Gillian Bates

PLoS One· March 2021

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Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms.
Christian Landles, Rebecca E Milton, Alexandre Jean, Stuart McLarnon, Sean J McAteer, Gillian P Bates

Brain Commun· January 2021

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Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model.
Christian Landles, Rebecca E Milton, Nadira Ali, Rachel Flomen, Michael Flower, Gillian P Bates

Brain Commun· August 2020

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