Publications by authors named "Gisela D Cymes"

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Disentangling the mechanistic role of loop-C capping in Cys-loop receptor activation.
Gisela D Cymes, Claudio Grosman

Nat Commun· November 2025

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GABA receptor gating imaged on the millisecond timescale.
Daniel B Mihaylov, Tomas Malinauskas, Gisela D Cymes, Jonas Miehling, Veronica T Chang

bioRxiv· September 2025

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Characterizing the Ion-Conductive State of the α7-Nicotinic Acetylcholine Receptor via Single-Channel Measurements and Molecular Dynamics Simulations.
Nauman Sultan, Gisela D Cymes, Ada Chen, Bernard Brooks, Claudio Grosman

bioRxiv· August 2025

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Electrically silent mutants unravel the mechanism of binding-gating coupling in Cys-loop receptors.
Nicole E Godellas, Gisela D Cymes, Claudio Grosman

Sci Adv· November 2024

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An experimental test of the nicotinic hypothesis of COVID-19.
Nicole E Godellas, Gisela D Cymes, Claudio Grosman

Proc Natl Acad Sci U S A· November 2022

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Structure and function at the lipid-protein interface of a pentameric ligand-gated ion channel.
Pramod Kumar, Gisela D Cymes, Claudio Grosman

Proc Natl Acad Sci U S A· June 2021

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Signal transduction through Cys-loop receptors is mediated by the nonspecific bumping of closely apposed domains.
Gisela D Cymes, Claudio Grosman

Proc Natl Acad Sci U S A· April 2021

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Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer.
Pramod Kumar, Yuhang Wang, Zhening Zhang, Zhiyu Zhao, Gisela D Cymes

Proc Natl Acad Sci U S A· January 2020

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Chasing the open-state structure of pentameric ligand-gated ion channels.
Giovanni Gonzalez-Gutierrez, Yuhang Wang, Gisela D Cymes, Emad Tajkhorshid, Claudio Grosman

J Gen Physiol· December 2017

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Identifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels.
Gisela D Cymes, Claudio Grosman

Proc Natl Acad Sci U S A· November 2016

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Engineered Ionizable Side Chains.
Gisela D Cymes, Claudio Grosman

Adv Exp Med Biol· March 2016

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The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors.
Gisela D Cymes, Claudio Grosman

Nat Chem Biol· December 2012

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Estimating the pKa values of basic and acidic side chains in ion channels using electrophysiological recordings: a robust approach to an elusive problem.
Gisela D Cymes, Claudio Grosman

Proteins· December 2011

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Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors.
Gisela D Cymes, Claudio Grosman

Nature· May 2011

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Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of "slow-channel syndrome" nicotinic receptor mutants.
Sergio Elenes, Michael Decker, Gisela D Cymes, Claudio Grosman

J Gen Physiol· February 2009

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Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer.
Gisela D Cymes, Claudio Grosman

Nat Struct Mol Biol· April 2008

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Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor.
Sergio Elenes, Ying Ni, Gisela D Cymes, Claudio Grosman

J Gen Physiol· November 2006

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Probing ion-channel pores one proton at a time.
Gisela D Cymes, Ying Ni, Claudio Grosman

Nature· December 2005

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Dynamics of the acetylcholine receptor pore at the gating transition state.
Ananya Mitra, Gisela D Cymes, Anthony Auerbach

Proc Natl Acad Sci U S A· October 2005

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Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.
Gisela D Cymes, Claudio Grosman, Anthony Auerbach

Biochemistry· April 2002

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