Publications by authors named "Ada Chen"

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PKAD-R: curated, redesigned and expanded database of experimental pKa values in proteins.
Ada Y Chen, Shailesh K Panday, Kaoru Ri, Emil Alexov, Bernard R Brooks

J Comput Biophys Chem· November 2025

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Characterizing the Ion-Conductive State of the α7-Nicotinic Acetylcholine Receptor via Single-Channel Measurements and Molecular Dynamics Simulations.
Nauman Sultan, Gisela D Cymes, Ada Chen, Bernard Brooks, Claudio Grosman

bioRxiv· August 2025

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Discovery of AB801, a Potent and Selective Inhibitor of AXL Receptor Tyrosine Kinase for Use in Cancer Therapy.
Dillon H Miles, Manjunath Lamani, Srinivas Reddy Paladugu, Shiwei Qu, Corinne N Foley, Ada Chen

J Med Chem· June 2025

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Benefits and barriers to return to education and relationship to quality of life for people living with spinal cord injury: Results of a mixed methods study.
Shelly Hsieh, Adria De Simone, Trevor Dyson-Hudson, John O'Neill, Amanda Botticello, Ada Chen

J Spinal Cord Med· March 2025

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Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors.
Amy E Anderson, Kaustubh Parashar, Ke Jin, Julie Clor, Carlo E Stagnaro, Ada Chen

Mol Cancer Ther· October 2024

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What structural and cultural organizational characteristics affect flexible work environments? Evidence from the 2017 and 2022 Kessler Foundation National Employment & Disability Survey: Supervisor Perspectives.
Hyun Ju Kim, Erica Jablonski, Debra L Brucker, Ada Chen, John O'Neill

J Vocat Rehabil· January 2024

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Ion channel selectivity through ion-modulated changes of selectivity filter p values.
Ada Y Chen, Bernard R Brooks, Ana Damjanovic

Proc Natl Acad Sci U S A· June 2023

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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity.
Dana Piovesan, Joanne B L Tan, Annette Becker, Jesus Banuelos, Nell Narasappa, Ada Chen

Mol Cancer Ther· June 2022

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Protein p Prediction by Tree-Based Machine Learning.
Ada Y Chen, Juyong Lee, Ana Damjanovic, Bernard R Brooks

J Chem Theory Comput· April 2022

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Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ).
Guillaume Mata, Dillon H Miles, Samuel L Drew, Jeremy Fournier, Kenneth V Lawson, Jie Chen, Ada Chen

J Med Chem· January 2022

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Determinants of conductance of a bacterial voltage-gated sodium channel.
Ada Y Chen, Bernard R Brooks, Ana Damjanovic

Biophys J· August 2021

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Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.
Ehesan U Sharif, Jaroslaw Kalisiak, Kenneth V Lawson, Dillon H Miles, Eric Newcomb, Ada Chen

J Med Chem· January 2021

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Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors.
Dillon H Miles, Xuelei Yan, Rhiannon Thomas-Tran, Jeremy Fournier, Ehesan U Sharif, Ada Chen, Jie Chen

ACS Med Chem Lett· November 2020

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Discovery of AB680: A Potent and Selective Inhibitor of CD73.
Kenneth V Lawson, Jaroslaw Kalisiak, Erick A Lindsey, Eric T Newcomb, Manmohan Reddy Leleti, Ada Chen

J Med Chem· October 2020

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Discovery of Potent and Selective PI3Kγ Inhibitors.
Samuel L Drew, Rhiannon Thomas-Tran, Joel W Beatty, Jeremy Fournier, Kenneth V Lawson, Jie Chen, Pei-Yu Chen, Ada Chen

J Med Chem· October 2020

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Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73.
Joel W Beatty, Erick A Lindsey, Rhiannon Thomas-Tran, Laurent Debien, Debashis Mandal, Ada Chen

J Med Chem· April 2020

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Protonation state of the selectivity filter of bacterial voltage-gated sodium channels is modulated by ions.
Ana Damjanovic, Ada Y Chen, Robert L Rosenberg, Daniel R Roe, Xiongwu Wu

Proteins· March 2020

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The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents.
Jude Canon, Tao Osgood, Steven H Olson, Anne Y Saiki, Rebecca Robertson, Ada Chen

Mol Cancer Ther· March 2015

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AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
Hang Chen, Dianna Lester-Zeiner, Jianxia Shi, Silke Miller, Charlie Glaus, Ning Chen, Ada Chen

J Pharmacol Exp Ther· February 2015

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Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
Yosup Rew, Daqing Sun, Xuelei Yan, Hilary P Beck, Jude Canon, Ada Chen

J Med Chem· December 2014

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Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Yingcai Wang, Jiang Zhu, Jiwen Jim Liu, Xiaoqi Chen, Jeff Mihalic, Ada Chen

Bioorg Med Chem Lett· August 2014

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Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
Ming Yu, Yingcai Wang, Jiang Zhu, Michael D Bartberger, Jude Canon, Ada Chen

ACS Med Chem Lett· August 2014

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Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.
Ana Z Gonzalez, Zhihong Li, Hilary P Beck, Jude Canon, Ada Chen

J Med Chem· April 2014

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Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W Gribble, Grace Q Alba, Ada Chen, Xiaoqi Chen, Pingchen Fan

J Med Chem· April 2014

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Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Ana Z Gonzalez, John Eksterowicz, Michael D Bartberger, Hilary P Beck, Jude Canon, Ada Chen

J Med Chem· March 2014

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