Publications by authors named "Giuseppina Tesco"

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Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knockin mouse model of Alzheimer disease.
Mattia Bonzanni, Alice Braga, Takashi Saito, Takaomi C Saido, Giuseppina Tesco

iScience· January 2025

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Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knock in mouse model of Alzheimer's disease.
Mattia Bonzanni, Alice Braga, Takashi Saito, Takaomi C Saido, Giuseppina Tesco

bioRxiv· April 2024

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3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.
Selene Lomoio, Ravi S Pandey, Nicolas Rouleau, Beatrice Menicacci, WonHee Kim, Giuseppina Tesco

Mol Psychiatry· December 2023

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A 3D Bioengineered Neural Tissue Model Generated from Human iPSC-Derived Neural Precursor Cells.
Selene Lomoio, Giuseppina Tesco

Methods Mol Biol· June 2023

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Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?
Giuseppina Tesco, Selene Lomoio

Semin Immunol· January 2022

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Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo.
WonHee Kim, Hiroto Watanabe, Selene Lomoio, Giuseppina Tesco

J Biol Chem· August 2021

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deletion and a rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings.
Selene Lomoio, Rachel Willen, WonHee Kim, Kevin Z Ho, Edward K Robinson, Giuseppina Tesco

Sci Transl Med· November 2020

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BACE1 partial deletion induces synaptic plasticity deficit in adult mice.
Sylvia Lombardo, Martina Chiacchiaretta, Andrew Tarr, WonHee Kim, Tingyi Cao, Giuseppina Tesco

Sci Rep· December 2019

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Functional and Sustainable 3D Human Neural Network Models from Pluripotent Stem Cells.
William Cantley, Chuang Du, Selene Lomoio, Thomas DePalma, Emily Peirent, Giuseppina Tesco

ACS Biomater Sci Eng· December 2018

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β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.
Stephanie Hartmann, Fang Zheng, Michele C Kyncl, Sandra Karch, Kerstin Voelkl, Giuseppina Tesco

J Neurosci· April 2018

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BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Giuseppina Tesco

Mol Neurodegener· February 2018

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Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.
Kendall R Walker, Amit Modgil, David Albrecht, Selene Lomoio, Philip G Haydon, Giuseppina Tesco

PLoS One· July 2017

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The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.
Eniola Funmilayo Aduke Yeates, Giuseppina Tesco

J Biol Chem· July 2016

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Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.
David Cantu, Kendall Walker, Lauren Andresen, Amaro Taylor-Weiner, David Hampton, Giuseppina Tesco

Cereb Cortex· August 2015

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Molecular mechanisms of cognitive dysfunction following traumatic brain injury.
Kendall R Walker, Giuseppina Tesco

Front Aging Neurosci· July 2013

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BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.
Eugene L Kang, Barbara Biscaro, Fabrizio Piazza, Giuseppina Tesco

J Biol Chem· December 2012

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Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease.
Barbara Biscaro, Olle Lindvall, Giuseppina Tesco, Christine T Ekdahl, Roger M Nitsch

Neurodegener Dis· October 2012

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Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Kendall R Walker, Eugene L Kang, Michael J Whalen, Yong Shen, Giuseppina Tesco

J Neurosci· July 2012

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Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.
Kara A Kittelberger, Fabrizio Piazza, Giuseppina Tesco, Leon G Reijmers

PLoS One· May 2012

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Autophagy: a common road to perdition in acute brain injuries and Alzheimer's disease.
Giuseppina Tesco

J Neurochem· February 2012

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Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice.
Rebekah C Mannix, Jimmy Zhang, Juyeon Park, Xuan Zhang, Kiran Bilal, Giuseppina Tesco

J Cereb Blood Flow Metab· January 2011

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Ubiquitin regulates GGA3-mediated degradation of BACE1.
Eugene L Kang, Andrew N Cameron, Fabrizio Piazza, Kendall R Walker, Giuseppina Tesco

J Biol Chem· July 2010

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Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.
Davide Gianni, Airong Li, Giuseppina Tesco, Kenneth M McKay, John Moore

Circulation· March 2010

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Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
Minji Kim, Jaehong Suh, Donna Romano, Mimy H Truong, Kristina Mullin, Giuseppina Tesco

Hum Mol Genet· October 2009

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Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Michael A Myre, Kevin Washicosky, Robert D Moir, Giuseppina Tesco, Rudolph E Tanzi

Cell Signal· April 2009

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