Publications by authors named "Govindarajan Manikumar"

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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
David J Adams, William R Waud, Mansukh C Wani, Govindarajan Manikumar, James L Flowers

Cancer Chemother Pharmacol· April 2011

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Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.
Patrick J Burke, Peter D Senter, David W Meyer, Jamie B Miyamoto, Martha Anderson, Govindarajan Manikumar

Bioconjug Chem· June 2009

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Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
Meredith T Morgan, Yuka Nakanishi, David J Kroll, Aaron P Griset, Michael A Carnahan, Govindarajan Manikumar

Cancer Res· December 2006

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Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.
David J Adams, Miriam L Wahl, James L Flowers, Banalata Sen, Michael Colvin, Govindarajan Manikumar

Cancer Chemother Pharmacol· January 2006

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Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
David J Adams, Mateus Webba da Silva, James L Flowers, Glenda Kohlhagen, Yves Pommier, Govindarajan Manikumar

Cancer Chemother Pharmacol· January 2006

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Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Govindarajan Manikumar, Randy M Wadkins, David Bearss, Daniel D Von Hoff, Mansukhlal C Wani

Bioorg Med Chem Lett· November 2004

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Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I.
Randy M Wadkins, David Bearss, Govindarajan Manikumar, Mansukhlal C Wani, Monroe E Wall

Cancer Res· September 2004

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Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity.
Randy M Wadkins, David Bearss, Govindarajan Manikumar, Mansukhlal C Wani, Monroe E Wall

Curr Med Chem Anticancer Agents· July 2004

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The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.
James L Flowers, Robert M Hoffman, Timothy A Driscoll, Monroe E Wall, Mansukh C Wani, Govindarajan Manikumar

Cancer Chemother Pharmacol· September 2003

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