Publications by authors named "Graeme Freestone"

Claim this Profile
S
Synthesis, Incorporation, and Translation Properties of Threose Nucleic Acid Modified Trinucleotide Cap Analogs.
Alexander Pontarelli, Guillermo Vasquez, Wuxia Fu, Qingxia Solan, Hans J Gaus, Graeme C Freestone

ACS Omega· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.
Michael E Østergaard, Michele Carrer, Brooke A Anderson, Megan Afetian, Mohsen A Bakooshli, Graeme C Freestone

Nucleic Acids Res· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Towards combining backbone and sugar constraint in 3'-3' bis-phosphonate tethered 2'-4' bridged LNA oligonucleotide trimers.
Edouard Duchamp, Guillermo Vasquez, Neda Firoozi, Graeme C Freestone, Michael Oestergaard

RSC Adv· July 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA.
Tamilselvan Rajasekaran, Graeme C Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Hans Gaus

J Org Chem· March 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'--Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.
Lingdi Zhang, Xue-Hai Liang, Cheryl Li De Hoyos, Michael Migawa, Joshua G Nichols, Graeme Freestone

Nucleic Acid Ther· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA.
Tamilselvan Rajasekaran, Graeme C Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Lorena Rico

J Am Chem Soc· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii

Nucleic Acids Res· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Guillermo Vasquez, Graeme C Freestone, W Brad Wan, Audrey Low, Cheryl Li De Hoyos

Nucleic Acids Res· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.
Andrew R Hudson, Vincent J Santora, Robert E Petroski, Theresa A Almos, Gary Anderson, Graeme C Freestone

Bioorg Med Chem Lett· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties.
Vincent J Santora, Theresa A Almos, Richard Barido, Jillian Basinger, Chris L Bellows, Graeme C Freestone

J Med Chem· July 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
Laurent Gomez, Mark Eben Massari, Troy Vickers, Graeme Freestone, William Vernier

J Med Chem· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems.
K C Nicolaou, Anthony A Estrada, Graeme C Freestone, Sang Hyup Lee, Xavier Alvarez-Mico

Tetrahedron· July 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones.
K C Nicolaou, Anthony A Estrada, Sang Hyup Lee, Graeme C Freestone

Angew Chem Int Ed Engl· August 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enantioselective partial reduction of 2,5-disubstituted pyrroles via a chiral protonation approach.
Timothy J Donohoe, Graeme C Freestone, Catherine E Headley, Caroline L Rigby, Rick P C Cousins

Org Lett· September 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of enantiopure dihydropyranones: aldol-based ring expansion of dihydrofurans.
Timothy J Donohoe, Ali Raoof, Graeme C Freestone, Ian D Linney, Andrew Cowley

Org Lett· September 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis