Publications by authors named "Ian D Linney"

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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Laura Carzaniga, Ian D Linney, Andrea Rizzi, Wolfgang Schmidt, Christopher K Knight

J Med Chem· June 2024

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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Laura Carzaniga, Ian D Linney, Andrea Rizzi, Maurizio Delcanale, Wolfgang Schmidt

J Med Chem· August 2022

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Inhibitors of immuno-oncology target HPK1 - a patent review (2016 to 2020).
Ian D Linney, Neelu Kaila

Expert Opin Ther Pat· October 2021

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Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Fabio Rancati, Ian D Linney, Andrea Rizzi, Maurizio Delcanale, Chris K Knight

Bioorg Med Chem Lett· June 2021

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Flexible strategy for the synthesis of pyrrolizidine alkaloids.
Timothy J Donohoe, Rhian E Thomas, Matthew D Cheeseman, Caroline L Rigby, Gurdip Bhalay, Ian D Linney

Org Lett· August 2008

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Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
John Spencer, John Gaffen, Eric Griffin, Elaine A Harper, Ian D Linney

Bioorg Med Chem· March 2008

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Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists.
Iain M McDonald, Carol Austin, Ildiko M Buck, David J Dunstone, John Gaffen, Ian D Linney

J Med Chem· October 2007

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Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion.
Iain M McDonald, James W Black, Ildiko M Buck, David J Dunstone, Eric P Griffin, Ian D Linney

J Med Chem· June 2007

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An enzymatic approach to the desymmetrization of disubstituted pyrrolines.
Timothy J Donohoe, Caroline L Rigby, Rhian E Thomas, William F Nieuwenhuys, Farrah L Bhatti, Ian D Linney

J Org Chem· August 2006

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Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK(2) antagonists that display high selectivity over CCK(1) receptors.
Iain M McDonald, Carol Austin, Ildiko M Buck, David J Dunstone, Eric Griffin, Ian D Linney

J Med Chem· April 2006

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Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
Ildiko M Buck, James W Black, Tracey Cooke, David J Dunstone, John D Gaffen, Ian D Linney

J Med Chem· November 2005

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Synthesis of enantiopure dihydropyranones: aldol-based ring expansion of dihydrofurans.
Timothy J Donohoe, Ali Raoof, Graeme C Freestone, Ian D Linney, Andrew Cowley

Org Lett· September 2002

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