Publications by authors named "Graham Douglas"

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Longitudinal single-cell analysis reveals treatment-resistant stem and mast cells with potential treatments for pediatric AML.
Denis Ohlstrom, Mojtaba Bakhtiari, Hope Mumme, Marina Michaud, Alejandro De Janon Gutierrez, Douglas Graham

Leukemia· November 2025

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Correction: Longitudinal single-cell analysis reveals treatment-resistant stem and mast cells with potential treatments for pediatric AML.
Denis Ohlstrom, Mojtaba Bakhtiari, Hope Mumme, Marina Michaud, Alejandro De Janon Gutierrez, Douglas Graham

Leukemia· November 2025

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iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation.
Stephanie Springborn, Samantha Judd, Patricia Morateck, David VanderZee, Adam Kidwell, Douglas K Graham

Blood Vessel Thromb Hemost· August 2025

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Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors.
Megan D Hopkins, Dehui Zhang, Zhilong Chen, Andrew L McIver, Justus M Huelse, Douglas K Graham

Eur J Med Chem· June 2025

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Prospects of current AXL-targeting therapies in early phase cancer trials.
Juhye Yim, Chloe Hope, Justus M Huelse, Douglas K Graham

Expert Opin Investig Drugs· June 2025

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Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas.
Hope L Mumme, Chenbin Huang, Denis Ohlstrom, Mojtaba Bakhtiari, Sunil S Raikar, Douglas K Graham

Nat Commun· May 2025

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Discovery of Novel TYRO3/MERTK Dual Inhibitors.
Deyu Kong, Jichen Zhao, Daowei Huang, Michael A Stashko, Dan Yan, Douglas K Graham

J Med Chem· April 2025

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UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor.
Deyu Kong, Xiangbo Yang, Samantha Judd, Dan Yan, Stephanie Springborn, Douglas K Graham

J Med Chem· March 2025

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MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity.
Justus M Huelse, Swati S Bhasin, Kristen M Jacobsen, Juhye Yim, Beena E Thomas, Douglas K Graham

Leukemia· December 2024

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Tobacco, nicotine, and cannabis use and exposure in an Australian Indigenous population during pregnancy: A protocol to measure parental and foetal exposure and outcomes.
Angela Ratsch, Elizabeth A Burmeister, Aunty Veronica Bird, Aunty Joyce Bonner, Uncle Glen Miller, Graham Douglas

PLoS One· September 2024

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MERTK Is a Potential Therapeutic Target in Ewing Sarcoma.
Sherri K Smart, Tsz Y Yeung, M Olivia Santos, Leon F McSwain, Xiaodong Wang, Douglas K Graham

Cancers (Basel)· August 2024

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MERTK Inhibition as a Targeted Novel Cancer Therapy.
K M Tanim, Alisha Holtzhausen, Aashis Thapa, Justus M Huelse, Douglas K Graham

Int J Mol Sci· July 2024

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Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.
Deyu Kong, Qiang Tian, Zhilong Chen, Hongchao Zheng, Michael A Stashko, Douglas K Graham

J Med Chem· April 2024

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TAM family kinases as therapeutic targets at the interface of cancer and immunity.
Deborah DeRyckere, Justus M Huelse, H Shelton Earp, Douglas K Graham

Nat Rev Clin Oncol· November 2023

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Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia.
Hope Mumme, Beena E Thomas, Swati S Bhasin, Upaasana Krishnan, Bhakti Dwivedi, Douglas K Graham

Nat Commun· October 2023

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Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia.
Hope L Mumme, Sunil S Raikar, Swati S Bhasin, Beena E Thomas, Taylor Lawrence, Douglas K Graham

Genome Med· October 2023

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Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia.
James M Kelvin, Madison L Chimenti, Dan Y Zhang, Evelyn K Williams, Samuel G Moore, Douglas K Graham

J Control Release· September 2023

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Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML.
James M Kelvin, Juhi Jain, Aashis Thapa, Min Qui, Lacey A Birnbaum, Douglas K Graham

Pharm Res· September 2023

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In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies.
Yekaterina Galat, Yuchen Du, Mariana Perepitchka, Xiao-Nan Li, Irina V Balyasnikova, Douglas K Graham

Oncoimmunology· September 2023

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Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis.
Swati S Bhasin, Beena E Thomas, Ryan J Summers, Debasree Sarkar, Hope Mumme, Douglas K Graham

Sci Rep· August 2023

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Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment.
Joselyn Cruz Cruz, Kristen C Allison, Lauren S Page, Alexis J Jenkins, Xiaodong Wang, Douglas K Graham

Front Immunol· March 2023

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Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML.
James M Kelvin, Juhi Jain, Aashis Thapa, Min Qui, Lacey A Birnbaum, Douglas K Graham

bioRxiv· March 2023

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Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia.
Ryan J Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison L Chimenti, Douglas K Graham

Cancers (Basel)· December 2022

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MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer.
Dan Yan, Justus M Huelse, Dmitri Kireev, Zikang Tan, Luxiao Chen, Douglas K Graham

J Clin Invest· August 2022

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Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care.
Ryan J Summers, Sharon M Castellino, Christopher C Porter, Tobey J MacDonald, Gargi D Basu, Douglas K Graham

JCO Precis Oncol· April 2022

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