Publications by authors named "Graham H Coombs"

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Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes.
Marco Biddau, T R Santha Kumar, Philipp Henrich, Larissa M Laine, Gavin J Blackburn, Graham H Coombs

Int J Parasitol· May 2021

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Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine.
Gareth D Westrop, Lijie Wang, Gavin J Blackburn, Tong Zhang, Liang Zheng, Graham H Coombs

PLoS One· January 2018

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Graham H Coombs

Autophagy· October 2016

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Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism.
Gareth D Westrop, Roderick A M Williams, Lijie Wang, Tong Zhang, David G Watson, Graham H Coombs

PLoS One· June 2016

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Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.
Karen McLuskey, Jaspreet S Grewal, Debanu Das, Adam Godzik, Scott A Lesley, Graham H Coombs

J Biol Chem· April 2016

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PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.
Jaspreet S Grewal, Karen McLuskey, Debanu Das, Elmarie Myburgh, Jonathan Wilkes, Graham H Coombs

J Biol Chem· April 2016

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Glycosome turnover in Leishmania major is mediated by autophagy.
Benjamin Cull, Joseane Lima Prado Godinho, Juliany Cola Fernandes Rodrigues, Benjamin Frank, Uta Schurigt, Graham H Coombs

Autophagy· December 2015

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Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites.
Rong Zhang, David G Watson, Lijie Wang, Gareth D Westrop, Graham H Coombs

J Chromatogr A· October 2014

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Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.
Wagner A S Judice, Marcella A Manfredi, Gerson P Souza, Thiago M Sansevero, Paulo C Almeida, Graham H Coombs

PLoS One· September 2014

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Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.
Jörg Schröder, Sandra Noack, Richard J Marhöfer, Jeremy C Mottram, Graham H Coombs

PLoS One· August 2014

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Tracking autophagy during proliferation and differentiation of .
William R Proto, Nathaniel G Jones, Graham H Coombs, Jeremy C Mottram

Microb Cell· January 2014

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Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism.
Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Graham H Coombs

PLoS Pathog· January 2014

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Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation.
Andrew M Tomlins, Fathia Ben-Rached, Roderick Am Williams, William R Proto, Isabelle Coppens, Graham H Coombs

Autophagy· October 2013

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Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major.
Roderick A M Williams, Jeremy C Mottram, Graham H Coombs

J Biol Chem· February 2013

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Cell death in parasitic protozoa: regulated or incidental?
William R Proto, Graham H Coombs, Jeremy C Mottram

Nat Rev Microbiol· January 2013

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ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major.
Roderick A M Williams, Terry K Smith, Benjamin Cull, Jeremy C Mottram, Graham H Coombs

PLoS Pathog· November 2012

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Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation.
Lesley S Morrison, Amy Goundry, Marilia S Faria, Laurence Tetley, Sylvain C Eschenlauer, Graham H Coombs

Cell Microbiol· August 2012

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Structure of Leishmania major cysteine synthase.
Paul K Fyfe, Gareth D Westrop, Tania Ramos, Sylke Müller, Graham H Coombs

Acta Crystallogr Sect F Struct Biol Cryst Commun· July 2012

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Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation.
Paul K Fyfe, Gareth D Westrop, Ana Marta Silva, Graham H Coombs, William N Hunter

Proc Natl Acad Sci U S A· July 2012

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Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.
Saskia Decuypere, Manu Vanaerschot, Kirstyn Brunker, Hideo Imamura, Sylke Müller, Graham H Coombs

PLoS Negl Trop Dis· June 2012

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Crystal structure of a Trypanosoma brucei metacaspase.
Karen McLuskey, Jana Rudolf, William R Proto, Neil W Isaacs, Graham H Coombs

Proc Natl Acad Sci U S A· May 2012

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Guidelines for the use and interpretation of assays for monitoring autophagy.
Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Graham H Coombs

Autophagy· April 2012

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Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella.
Marie Schaeffer, Joerg Schroeder, Anja R Heckeroth, Sandra Noack, Michael Gassel, Graham H Coombs

Antimicrob Agents Chemother· March 2012

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Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.
Tim Downing, Hideo Imamura, Saskia Decuypere, Taane G Clark, Graham H Coombs

Genome Res· December 2011

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Metabolic variation during development in culture of Leishmania donovani promastigotes.
Ana Marta Silva, Anabela Cordeiro-da-Silva, Graham H Coombs

PLoS Negl Trop Dis· December 2011

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