Publications by authors named "Tim Downing"

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Competencies for bioinformatics core facility scientists: extension of the ISCB competency framework for bioinformatics.
Marta Lloret-Llinares, Patricia Carvajal-López, Tim Downing, Madelaine Gogol, Shannan Ho Sui

Bioinform Adv· October 2025

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Genetic coping mechanisms observed in Leishmania tropica, from the Middle East region, enhance the survival of the parasite after drug exposure.
Hedvig Glans, Gabriel M Matos, Maria Bradley, Tim Downing, Björn Andersson

PLoS One· December 2024

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Protection against β-N-methylamino-l-alanineꟷinduced vesicular monoamine transporter 2 inhibition by hydroxyl-containing proteinogenic amino acids.
Rianita van Onselen, Chanté Kennedy, Tim G Downing

Environ Toxicol Pharmacol· April 2024

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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa.
Ismar R Haga, Barbara B Shih, Gessica Tore, Noemi Polo, Paolo Ribeca, Tim Downing

Viruses· April 2024

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Uptake of β-N-methylamino-L-alanine (BMAA) into glutamate-specific synaptic vesicles: Exploring the validity of the excitotoxicity mechanism of BMAA.
Rianita van Onselen, Tim G Downing

Neurosci Lett· January 2024

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A primer on correlation-based dimension reduction methods for multi-omics analysis.
Tim Downing, Nicos Angelopoulos

J R Soc Interface· October 2023

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β-N-methylamino-l-alanine is a non-competitive inhibitor of vesicular monoamine transporter 2.
Chanté Kennedy, Rianita van Onselen, Tim G Downing

Toxicon· January 2023

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Informing plasmid compatibility with bacterial hosts using protein-protein interaction data.
Tim Downing, Min Jie Lee, Conor Archbold, Adam McDonnell, Alexander Rahm

Genomics· November 2022

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Bacterial plasmid-associated and chromosomal proteins have fundamentally different properties in protein interaction networks.
Tim Downing, Alexander Rahm

Sci Rep· November 2022

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Data pertaining to aberrant intracellular calcium handling during androgen deprivation therapy in prostate cancer.
Debbie O'Reilly, Tim Downing, Sana Kouba, Marie Potier-Cartereau, Declan J McKenna

Data Brief· June 2022

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Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer.
Alex J Eustace, Min Jie Lee, Grace Colley, Jack Roban, Tim Downing

Cancer Drug Resist· June 2022

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CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer.
Debbie O'Reilly, Tim Downing, Sana Kouba, Marie Potier-Cartereau, Declan J McKenna

Cell Calcium· May 2022

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Neonatal Reserpine Administration Produces Widespread Neuronal Losses and ⍺-Synuclein Inclusions in a Rat Model.
Rianita van Onselen, Tim G Downing

Neurotox Res· December 2021

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High genome plasticity and frequent genetic exchange in Leishmania tropica isolates from Afghanistan, Iran and Syria.
Hedvig Glans, Maria Lind Karlberg, Reza Advani, Maria Bradley, Erik Alm, Tim Downing

PLoS Negl Trop Dis· December 2021

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Plasmids shape the diverse accessory resistomes of ST131.
Arun Gonzales Decano, Nghia Tran, Hawriya Al-Foori, Buthaina Al-Awadi, Leigh Campbell, Tim Downing

Access Microbiol· November 2020

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Evaluating amino acids as protectants against β-N-methylamino-l-alanine-induced developmental neurotoxicity in a rat model.
Rianita van Onselen, Laura Louise Scott, Tim G Downing

Toxicol Appl Pharmacol· September 2020

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Genomic surveillance of ST131 identifies local expansion and serial replacement of subclones.
Catherine Ludden, Arun Gonzales Decano, Dorota Jamrozy, Derek Pickard, Dearbhaile Morris, Tim Downing

Microb Genom· April 2020

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Global genome diversity of the complex.
Susanne U Franssen, Caroline Durrant, Olivia Stark, Bettina Moser, Tim Downing

Elife· March 2020

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β- N-methylamino-L-alanine Inhibits Human Catalase Activity: Possible Implications for Neurodegenerative Disease Development.
Rianita van Onselen, Tim G Downing

Int J Toxicol· January 2020

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An Escherichia coli ST131 pangenome atlas reveals population structure and evolution across 4,071 isolates.
Arun Gonzales Decano, Tim Downing

Sci Rep· November 2019

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Paternally Expressed Imprinted Genes under Positive Darwinian Selection in Arabidopsis thaliana.
Reetu Tuteja, Peter C McKeown, Pat Ryan, Claire C Morgan, Mark T A Donoghue, Tim Downing

Mol Biol Evol· June 2019

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Complete Assembly of Escherichia coli Sequence Type 131 Genomes Using Long Reads Demonstrates Antibiotic Resistance Gene Variation within Diverse Plasmid and Chromosomal Contexts.
Arun Gonzales Decano, Catherine Ludden, Theresa Feltwell, Kim Judge, Julian Parkhill, Tim Downing

mSphere· May 2019

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Potential for dietary exposure to β-N-methylamino-L-alanine and microcystin from a freshwater system.
Laura L Scott, Simoné Downing, Tim Downing

Toxicon· August 2018

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Development and Evaluation of a Novel Loop-Mediated Isothermal Amplification Assay for Diagnosis of Cutaneous and Visceral Leishmaniasis.
Emily Rebecca Adams, Gerard Schoone, Inge Versteeg, Maria Adelaida Gomez, Ermias Diro, Tim Downing

J Clin Microbiol· July 2018

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and reference genomes highlight genome structure and gene evolution in the subgenus.
Simone Coughlan, Ali Shirley Taylor, Eoghan Feane, Mandy Sanders, Gabriele Schonian, Tim Downing

R Soc Open Sci· April 2018

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