Publications by authors named "Graham L Smith"

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Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
Ted W Johnson, Paul F Richardson, Simon Bailey, Alexei Brooun, Benjamin J Burke, Graham L Smith

J Med Chem· June 2014

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Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Qinhua Huang, Ted W Johnson, Simon Bailey, Alexei Brooun, Kevin D Bunker, Graham L Smith

J Med Chem· February 2014

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Acidic triazoles as soluble guanylate cyclase stimulators.
Lee R Roberts, Paul A Bradley, Mark E Bunnage, Katherine S England, David Fairman, Graham L Smith

Bioorg Med Chem Lett· November 2011

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Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.
Kevin K-C Liu, JinJiang Zhu, Graham L Smith, Min-Jean Yin, Simon Bailey

ACS Med Chem Lett· November 2011

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Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Ted W Johnson, Steven P Tanis, Scott L Butler, Deepak Dalvie, Dorothy M Delisle, Graham L Smith

J Med Chem· May 2011

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Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK.
Steven P Tanis, Michael B Plewe, Ted W Johnson, Scott L Butler, Deepak Dalvie, Graham L Smith

Bioorg Med Chem Lett· December 2010

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4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Kevin K-C Liu, Shubha Bagrodia, Simon Bailey, Hengmiao Cheng, Hui Chen, Graham L Smith

Bioorg Med Chem Lett· October 2010

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