Publications by authors named "Greg Coffey"

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Results from an open-label phase 2a study of cerdulatinib, a dual spleen tyrosine kinase/janus kinase inhibitor, in relapsed/refractory peripheral T-cell lymphoma.
Steven M Horwitz, Tatyana A Feldman, Jing Christine Ye, Michael S Khodadoust, Javier Munoz, Greg Coffey

Leuk Lymphoma· June 2025

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Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease.
Saborni Chakraborty, Bowie Yik-Ling Cheng, Desmond L Edwards, Joseph C Gonzalez, David Kung-Chun Chiu, Greg P Coffey

Immunity· January 2025

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An engineered immunomodulatory IgG1 Fc suppresses autoimmune inflammation through pathways shared with i.v. immunoglobulin.
Sunny L Sneed, Brian B Reese, Ana Fs Laureano, Sneha Ratnapriya, Isabella Fraschilla, Greg P Coffey

J Clin Invest· February 2024

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Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B-cell malignancies: Results of a phase I study.
Paul A Hamlin, Ian W Flinn, Nina Wagner-Johnston, Jan A Burger, Greg P Coffey

Am J Hematol· April 2019

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Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies.
Greg P Coffey, Jiajia Feng, Andreas Betz, Anjali Pandey, Matt Birrell

Clin Cancer Res· February 2019

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The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia.
Matthew D Blunt, Stefan Koehrer, Rachel C Dobson, Marta Larrayoz, Sarah Wilmore, Greg P Coffey

Clin Cancer Res· May 2017

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PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.
Greg Coffey, Aradhana Rani, Andreas Betz, Yvonne Pak, Helena Haberstock-Debic

J Clin Pharmacol· February 2017

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Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment.
Ailin Guo, Pin Lu, Greg Coffey, Pamela Conley, Anjali Pandey

Oncotarget· February 2017

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Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma.
Jiao Ma, Wei Xing, Greg Coffey, Karen Dresser, Kellie Lu

Oncotarget· December 2015

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The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer.
Greg Coffey, Andreas Betz, Francis DeGuzman, Yvonne Pak, Mayuko Inagaki

J Pharmacol Exp Ther· December 2014

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Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis.
Greg Coffey, Andreas Betz, Jonathan Graf, Gillian Stephens, Pei Hua Lin

Pharmacol Res Perspect· December 2013

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The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.
Stephen E Spurgeon, Greg Coffey, Luke B Fletcher, Russell Burke, Jeffrey W Tyner

J Pharmacol Exp Ther· February 2013

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Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis.
Greg Coffey, Francis DeGuzman, Mayuko Inagaki, Yvonne Pak, Suzanne M Delaney

J Pharmacol Exp Ther· February 2012

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SYK inhibition and response prediction in diffuse large B-cell lymphoma.
Shuhua Cheng, Greg Coffey, X Hannah Zhang, Rita Shaknovich, Zibo Song

Blood· December 2011

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Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin.
Greg P Coffey, Ranjani Rajapaksa, Raymond Liu, Orr Sharpe, Chiung-Chi Kuo

J Cell Sci· September 2009

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Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy.
Neil B Lineberry, Leon L Su, Jack T Lin, Greg P Coffey, Christine M Seroogy

J Immunol· August 2008

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Tissue distribution and receptor-mediated clearance of anti-CD11a antibody in mice.
Greg P Coffey, Judith A Fox, Susanne Pippig, Susan Palmieri, Barbara Reitz

Drug Metab Dispos· May 2005

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Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior.
Janet L Neisewander, Rita A Fuchs, Ly T L Tran-Nguyen, Suzanne M Weber, Greg P Coffey

Neuropsychopharmacology· August 2004

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