Publications by authors named "Gregory Hook"

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Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition.
Gregory Hook, Mark Kindy, Vivian Hook

J Alzheimers Dis· May 2023

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Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.
Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark Kindy, Vivian Hook

Pharmacol Rev· July 2022

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Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.
Michael C Yoon, Mitchell P Christy, Von V Phan, William H Gerwick, Gregory Hook, Vivian Hook

Biochemistry· February 2022

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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.
Michael C Yoon, Angelo Solania, Zhenze Jiang, Mitchell P Christy, Sonia Podvin, Gregory Hook, Vivian Hook

ACS Chem Biol· September 2021

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Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling.
Muzhou Jiang, Jie Meng, Fan Zeng, Hong Qing, Gregory Hook, Vivian Hook

J Neurochem· November 2020

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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Vivian Hook, Michael Yoon, Charles Mosier, Gen Ito, Sonia Podvin, Gregory Hook

Biochim Biophys Acta Proteins Proteom· August 2020

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Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid.
Angela M Boutté, Vivian Hook, Bharani Thangavelu, George Anis Sarkis, Brittany N Abbatiello, Gregory Hook

J Neurotrauma· July 2020

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Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Gregory Hook, J Steven Jacobsen, Kenneth Grabstein, Mark Kindy, Vivian Hook

Front Neurol· September 2015

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Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
Gregory Hook, Jin Yu, Thomas Toneff, Mark Kindy, Vivian Hook

J Alzheimers Dis· January 2015

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The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury.
Gregory R Hook, Jin Yu, Nancy Sipes, Michael D Pierschbacher, Vivian Hook

J Neurotrauma· March 2014

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Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence.
Mark S Kindy, Jin Yu, Hong Zhu, Salim S El-Amouri, Vivian Hook, Gregory R Hook

J Alzheimers Dis· August 2012

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The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.
Gregory Hook, Vivian Hook, Mark Kindy

J Alzheimers Dis· January 2012

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Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.
Vivian Hook, Lydiane Funkelstein, Jill Wegrzyn, Steven Bark, Mark Kindy, Gregory Hook

Biochim Biophys Acta· January 2012

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Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.
Vivian Hook, Gregory Hook, Mark Kindy

Biol Chem· August 2010

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Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.
Vivian Y H Hook, Mark Kindy, Thomas Reinheckel, Christoph Peters, Gregory Hook

Biochem Biophys Res Commun· August 2009

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Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease.
Vivian Hook, Israel Schechter, Hans-Ulrich Demuth, Gregory Hook

Biol Chem· August 2008

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Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Vivian Y H Hook, Mark Kindy, Gregory Hook

J Biol Chem· March 2008

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Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics.
Gregory Hook, Vivian Y H Hook, Mark Kindy

Biol Chem· September 2007

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Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Vivian Hook, Mark Kindy, Gregory Hook

Biol Chem· February 2007

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Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.
Vivian Hook, Thomas Toneff, Matthew Bogyo, Doron Greenbaum, Katalin F Medzihradszky, Gregory Hook

Biol Chem· September 2005

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