Publications by authors named "Gregory Howard"

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Structural determinants and biochemical characterization of LORELEI as a GPI-anchored protein.
Yanbing Wang, Xunliang Liu, Nicholas Desnoyer, Gregory Howard, Ravishankar Palanivelu

Plant Physiol· December 2025

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An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy.
Yining Zhu, Zhi-Cheng Yao, Shuyi Li, Jingyao Ma, Christine Wei, Gregory P Howard

Nat Commun· July 2025

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Ribosome-directed cancer therapies: the tip of the iceberg?
Gregory C Howard, William P Tansey

Trends Pharmacol Sci· April 2025

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mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy.
Yining Zhu, Zhi-Cheng Yao, Shuyi Li, Jingyao Ma, Christine Wei, Gregory P Howard

bioRxiv· January 2025

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Development of the continuous ambulatory vestibular assessment (CAVA) system to provide an automatic diagnosis for vestibular conditions: protocol for a multicentre, single-arm, non-randomised clinical trial.
John S Phillips, Stephen J Cox, Gregory Howard, Juliet High, Louisa Murdin

BMJ Open· November 2024

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Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies.
Christian T Meyer, Brianna N Smith, Jing Wang, Kevin B Teuscher, Brian C Grieb, Gregory C Howard

Proc Natl Acad Sci U S A· August 2024

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Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity.
Yining Zhu, Jingyao Ma, Ruochen Shen, Jinghan Lin, Shuyi Li, Gregory P Howard

Nat Biomed Eng· May 2024

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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel

Elife· April 2024

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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Gregory C Howard, Jing Wang, Kristie Lindsey Rose, Camden Jones, Purvi Patel

bioRxiv· January 2024

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BabyBreathe trial: protocol for a randomised controlled trial of a complex intervention to prevent postpartum return to smoking.
Caitlin Notley, Tracey J Brown, Linda Bauld, Allan B Clark, Sharon Duneclift, Gregory Howard

BMJ Open· September 2023

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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Gregory C Howard

Proc Natl Acad Sci U S A· January 2023

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Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells.
Andrea C Florian, Chase M Woodley, Jing Wang, Brian C Grieb, Macey J Slota, Gregory C Howard

NAR Cancer· March 2022

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WIN site inhibition disrupts a subset of WDR5 function.
Andrew J Siladi, Jing Wang, Andrea C Florian, Lance R Thomas, Joy H Creighton, Gregory C Howard

Sci Rep· February 2022

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Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury and repair.
Philip J Hanwright, Chenhu Qiu, Jennifer Rath, Yang Zhou, Nicholas von Guionneau, Gregory P Howard

Biomaterials· January 2022

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Immunopotentiation by Lymph-Node Targeting of a Malaria Transmission-Blocking Nanovaccine.
Gregory P Howard, Nicole G Bender, Prachi Khare, Borja López-Gutiérrez, Vincent Nyasembe

Front Immunol· December 2021

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Implementing supportive exercise interventions in the colorectal cancer care pathway: a process evaluation of the PREPARE-ABC randomised controlled trial.
Jamie Murdoch, Anna Varley, Jane McCulloch, Megan Jones, Laura B Thomas, Gregory Howard

BMC Cancer· October 2021

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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.
Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu

Elife· January 2021

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Physical and chemical profiles of nanoparticles for lymphatic targeting.
Xiyu Ke, Gregory P Howard, Haoyu Tang, Bei Cheng, May Tun Saung

Adv Drug Deliv Rev· October 2020

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AtPIG-S, a predicted Glycosylphosphatidylinositol Transamidase subunit, is critical for pollen tube growth in Arabidopsis.
Nicholas Desnoyer, Gregory Howard, Emma Jong, Ravishankar Palanivelu

BMC Plant Biol· August 2020

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Biodegradable PLGA--PEG Nanoparticles Induce T Helper 2 (Th2) Immune Responses and Sustained Antibody Titers via TLR9 Stimulation.
Kirsty L Wilson, Gregory P Howard, Heather Coatsworth, Rhoel R Dinglasan, Hai-Quan Mao

Vaccines (Basel)· May 2020

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WDR5 is a conserved regulator of protein synthesis gene expression.
Audra F Bryan, Jing Wang, Gregory C Howard, Alissa D Guarnaccia, Chase M Woodley

Nucleic Acids Res· April 2020

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Particulate carrier systems as adjuvants for cancer vaccines.
May Tun Saung, Xiyu Ke, Gregory P Howard, Lei Zheng, Hai-Quan Mao

Biomater Sci· November 2019

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Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients.
Nick Leavey, Simon P Hammond, Lee Shepstone, Jane Cross, Henrik Zetterberg, Gregory Howard

BMC Neurol· September 2019

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Kinetic Control in Assembly of Plasmid DNA/Polycation Complex Nanoparticles.
Yizong Hu, Zhiyu He, Yue Hao, Like Gong, Marion Pang, Gregory P Howard

ACS Nano· September 2019

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Inhibition of MYC by the SMARCB1 tumor suppressor.
April M Weissmiller, Jing Wang, Shelly L Lorey, Gregory C Howard, Ernest Martinez

Nat Commun· May 2019

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