Publications by authors named "Somenath Chowdhury"

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Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models.
Connor A Ott, Timothy J Purwin, Pan-Yu Chen, Somenath Chowdhury, George L Mellor

Nat Commun· November 2025

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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai

Proc Natl Acad Sci U S A· January 2023

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Type II DNA topoisomerases in trypanosomatid and apicomplexan parasites.
Somenath Roy Chowdhury, Arpita Bhoumik, Vivek Kumar Gupta, Hemanta K Majumder

Acta Trop· October 2022

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TDP1 knockout Leishmania donovani accumulate topoisomerase 1-linked DNA damage and are hypersensitive to clinically used antileishmanial drugs.
Somenath Roy Chowdhury, Subhendu K Das, Bijoylaxmi Banerjee, Srijita Paul Chowdhuri, Hemanta K Majumder

FASEB J· April 2022

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DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives.
Sourav Saha, Somenath Roy Chowdhury, Hemanta K Majumder

Curr Issues Mol Biol· June 2020

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Divergent Synthesis and Evaluation of the in vitro Cytotoxicity Profiles of 3,4-Ethylenedioxythiophenyl-2-propen-1-one Analogues.
Jayachandran Karunakaran, Nachiappan Dhatchana Moorthy, Somenath Roy Chowdhury, Saleem Iqbal, Hemanta K Majumder

ChemMedChem· August 2019

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DNA Topoisomerases in Unicellular Pathogens: Structure, Function, and Druggability.
Somenath Roy Chowdhury, Hemanta K Majumder

Trends Biochem Sci· May 2019

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Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites.
Somenath Roy Chowdhury, Joseane Lima Prado Godinho, Jayaraman Vinayagam, Aline Araujo Zuma, Sara Teixeira De Macedo Silva

Sci Rep· August 2018

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Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
Bose Muthu Ramalingam, Nachiappan Dhatchana Moorthy, Somenath Roy Chowdhury, Thiyagarajan Mageshwaran, Elangovan Vellaichamy

J Med Chem· February 2018

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Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB.
Somenath Roy Chowdhury, Ashish Kumar, Joseane Lima Prado Godinho, Sara Teixeira De Macedo Silva, Aline Araujo Zuma

Biochem Pharmacol· August 2017

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A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase.
Sourav Saha, Chiranjit Acharya, Uttam Pal, Somenath Roy Chowdhury, Kahini Sarkar

Antimicrob Agents Chemother· October 2016

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A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani.
Ashish Kumar, Somenath Roy Chowdhury, Tapas Sarkar, Tulika Chakrabarti, Hemanta K Majumder

Fitoterapia· March 2016

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Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.
R Jeffrey Neitz, Clifford Bryant, Steven Chen, Jiri Gut, Estefania Hugo Caselli, Somenath Chowdhury

Bioorg Med Chem Lett· November 2015

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Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.
Kristina Oresic Bender, Leslie Ofori, Wouter A van der Linden, Elliot D Mock, Gopal K Datta, Somenath Chowdhury

J Am Chem Soc· April 2015

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Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method.
Haya Jamali, Hasan A Khan, Joseph R Stringer, Somenath Chowdhury, Jonathan A Ellman

J Am Chem Soc· March 2015

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Anthocephaline, a new indole alkaloid and cadambine, a potent inhibitor of DNA topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba.
Ashish Kumar, Somenath Roy Chowdhury, Kumar Kalyan Jatte, Tulika Chakrabarti, Hemanta K Majumder

Nat Prod Commun· February 2015

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Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response.
Amartya Mishra, Jayaraman Vinayagam, Sourav Saha, Sayan Chowdhury, Somenath Roy Chowdhury

Pharmacol Res Perspect· December 2014

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Disuccinyl betulin triggers metacaspase-dependent endonuclease G-mediated cell death in unicellular protozoan parasite Leishmania donovani.
Sayan Chowdhury, Tulika Mukherjee, Somenath Roy Chowdhury, Souvik Sengupta, Sibabrata Mukhopadhyay

Antimicrob Agents Chemother· November 2014

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A new ellagic acid glycoside and DNA topoisomerase IB inhibitory activity of saponins from Putranjiva roxburghii.
Ashish Kumar, Somenath Roy Chowdhury, Tulika Chakrabarti, Hemanta K Majumdarb, Tarun Jha

Nat Prod Commun· May 2014

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The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo.
Sourav Saha, Tulika Mukherjee, Sayan Chowdhury, Amartya Mishra, Somenath Roy Chowdhury

Biochem Pharmacol· December 2013

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Asymmetric synthesis of amines using tert-butanesulfinamide.
Hai-Chao Xu, Somenath Chowdhury, Jonathan A Ellman

Nat Protoc· November 2013

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Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites.
Yi Xue, Somenath Chowdhury, Xuying Liu, Yoshinori Akiyama, Jonathan Ellman

Biochemistry· May 2012

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Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase.
Sayan Chowdhury, Tulika Mukherjee, Souvik Sengupta, Somenath Roy Chowdhury, Sibabrata Mukhopadhyay

Mol Pharmacol· October 2011

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Ultrasensitive determination of cysteine based on the photocurrent of nafion-functionalized CdS-MV quantum dots on an ITO electrode.
Yi-Tao Long, Cong Kong, Da-Wei Li, Yang Li, Somenath Chowdhury

Small· June 2011

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Mapping allostery through the covariance analysis of NMR chemical shifts.
Rajeevan Selvaratnam, Somenath Chowdhury, Bryan VanSchouwen, Giuseppe Melacini

Proc Natl Acad Sci U S A· April 2011

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