Publications by authors named "Gregory Keele"

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Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance.
Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor

Cell Genom· November 2025

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Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacy.
Matthew S Karafin, Aaron V Issaian, Shaun Bevers, Julie A Reisz, Ariel Hay, Gregory R Keele

bioRxiv· November 2025

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Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent -Nitroso Transfer.
Aaron V Issaian, Monika Dzieciatkowska, Shaun Bevers, Safari Zohreh, Ariel Hay, Gregory R Keele

bioRxiv· November 2025

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Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity.
Monika Dzieciatkowska, Ariel Hay, Aaron Issaian, Gregory R Keele, Shaun Bevers

Haematologica· September 2025

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Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress.
Yue Dou, Danny Qiu, Vivien Li, Maja E Wierzbińska, Gregory R Keele

bioRxiv· July 2025

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Expanding the landscape of aging via orbitrap astral mass spectrometry and tandem mass tag integration.
Gregory R Keele, Yue Dou, Seth P Kodikara, Erin D Jeffery, Dina L Bai

Nat Commun· May 2025

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Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity.
Monika Dzieciatkowska, Ariel Hay, Aaron Issaian, Gregory R Keele, Shaun Bevers

bioRxiv· May 2025

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Red blood cell urate levels are linked to hemolysis in vitro and post-transfusion as a function of donor sex, population and genetic polymorphisms in SLC2A9 and ABCG2.
Alicia M Key, Eric J Earley, Vassilis L Tzounakas, Alkmini T Anastasiadi, Travis Nemkov, Gregory R Keele

Transfusion· March 2025

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Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools.
Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor

bioRxiv· March 2025

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Arginine metabolism is a biomarker of red blood cell and human aging.
Julie A Reisz, Eric J Earley, Travis Nemkov, Alicia Key, Daniel Stephenson, Gregory R Keele

Aging Cell· February 2025

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Ferroptosis regulates hemolysis in stored murine and human red blood cells.
Angelo D'Alessandro, Gregory R Keele, Ariel Hay, Travis Nemkov, Eric J Earley

Blood· February 2025

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Expanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) Integration.
Gregory R Keele, Yue Dou, Seth P Kodikara, Erin D Jeffery, Dina Bai

bioRxiv· December 2024

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Co-transfection of murine NXPE2 and murine glycophorin A confers reactivity with Ter-119.
Gregory R Keele, Ariel M Hay, Nadia K Holness, Arijita Jash, Sarah E Ewald

Haematologica· November 2024

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Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.
Travis Nemkov, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay

Cell Metab· September 2024

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Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes.
Travis Nemkov, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay

bioRxiv· June 2024

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Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro.
Travis Nemkov, Alicia Key, Daniel Stephenson, Eric J Earley, Gregory R Keele

Blood· June 2024

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Ferroptosis regulates hemolysis in stored murine and human red blood cells.
Angelo D'Alessandro, Gregory R Keele, Ariel Hay, Travis Nemkov, Eric J Earley

bioRxiv· June 2024

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Unraveling the genetics of arsenic toxicity with cellular morphology QTL.
Callan O'Connor, Gregory R Keele, Whitney Martin, Timothy Stodola, Daniel Gatti

PLoS Genet· April 2024

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Cell morphology QTL reveal gene by environment interactions in a genetically diverse cell population.
Callan O'Connor, Gregory R Keele, Whitney Martin, Timothy Stodola, Daniel Gatti

bioRxiv· November 2023

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Global and tissue-specific aging effects on murine proteomes.
Gregory R Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P Gygi

Cell Rep· July 2023

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The trouble with triples: Examining the impact of measurement error in mediation analysis.
Madeleine S Gastonguay, Gregory R Keele, Gary A Churchill

Genetics· May 2023

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Inferring cell-type-specific causal gene regulatory networks during human neurogenesis.
Nil Aygün, Dan Liang, Wesley L Crouse, Gregory R Keele, Michael I Love

Genome Biol· May 2023

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Author Correction: Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut.
Qijun Zhang, Vanessa Linke, Katherine A Overmyer, Lindsay L Traeger, Kazuyuki Kasahara, Gregory R Keele

Nat Microbiol· April 2023

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Genetic dissection of the pluripotent proteome through multi-omics data integration.
Selcan Aydin, Duy T Pham, Tian Zhang, Gregory R Keele, Daniel A Skelly

Cell Genom· April 2023

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Multi-omics analysis identifies drivers of protein phosphorylation.
Tian Zhang, Gregory R Keele, Isabela Gerdes Gyuricza, Matthew Vincent, Catherine Brunton

Genome Biol· March 2023

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