Publications by authors named "Gregory T Notte"

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Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect.
Laurent Debien, Megan K Armstrong, Joshua D Farr, Ryan D Ferrao, Pancham Lal Gupta, Gregory T Notte

J Med Chem· December 2025

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Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.
Doris T Tang, Zhimin Du, Kin S Yang, Brian P Bestvater, Joshua Kaplan, Gregory T Notte

J Med Chem· March 2025

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus.
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Gregory T Notte

PLoS One· December 2022

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Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
Julie Farand, Jeffrey E Kropf, Peter Blomgren, Jianjun Xu, Aaron C Schmitt, Gregory T Notte

ACS Med Chem Lett· March 2020

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ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
John T Liles, Britton K Corkey, Gregory T Notte, Grant R Budas, Eric B Lansdon

J Clin Invest· October 2018

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Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.
Gyrid Nygaard, Julie A Di Paolo, Deepa Hammaker, David L Boyle, Grant Budas, Gregory T Notte

Biochem Pharmacol· May 2018

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Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Julie Farand, Nicholas Mai, Jayaraman Chandrasekhar, Zachary E Newby, Josh Van Veldhuizen, Gregory T Notte

Bioorg Med Chem Lett· December 2016

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late Ii), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
Jeff A Zablocki, Elfatih Elzein, Xiaofen Li, Dmitry O Koltun, Eric Q Parkhill, Gregory T Notte

J Med Chem· October 2016

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Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
Dmitry O Koltun, Eric Q Parkhill, Elfatih Elzein, Tetsuya Kobayashi, Gregory T Notte

Bioorg Med Chem Lett· July 2016

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Highly enantioselective Mannich reactions with α-aryl silyl ketene acetals and imines.
Gregory T Notte, Jenny M Baxter Vu, James L Leighton

Org Lett· February 2011

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A new silicon lewis acid for highly enantioselective mannich reactions of aliphatic ketone-derived hydrazones.
Gregory T Notte, James L Leighton

J Am Chem Soc· May 2008

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Kinetic resolution of protected alpha-amino acid derivatives by a chiral O-nucleophilic acyl transfer catalyst.
Gregory T Notte, Tarek Sammakia

J Am Chem Soc· April 2006

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Kinetic resolution of alpha-acetoxy N-acyl oxazolidinethiones by a chiral O-nucleophilic acyl transfer catalyst.
Gregory T Notte, Tarek Sammakia, Peter J Steel

J Am Chem Soc· October 2005

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