Publications by authors named "Gretchen Poortinga"

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Reply to: The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.
Sehrish Kanwal, Natalie Brajanovski, Jiajun Zhan, Joanna Chan, Richard Rebello, Gretchen Poortinga

medRxiv· October 2025

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CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci.
Donald P Cameron, Jirawas Sornkom, Sameerh Alsahafi, Denis Drygin, Gretchen Poortinga

Biomedicines· July 2024

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Targeting the ribosome to treat multiple myeloma.
Kylee H Maclachlan, Kezia Gitareja, Jian Kang, Andrew Cuddihy, Yuxi Cao, Gretchen Poortinga

Mol Ther Oncol· March 2024

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Gretchen Poortinga

EMBO J· November 2020

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rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Jinbae Son, Katherine M Hannan, Gretchen Poortinga, Nadine Hein, Donald P Cameron

Front Cell Dev Biol· July 2020

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Gretchen Poortinga

Nat Commun· May 2020

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Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Gretchen Poortinga

Commun Biol· April 2020

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Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Gretchen Poortinga

Proc Natl Acad Sci U S A· September 2019

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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Gretchen Poortinga

Cancer Discov· August 2019

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Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
Claire A Martin, Carleen Cullinane, Laura Kirby, Shatha Abuhammad, Emily J Lelliott, Gretchen Poortinga

Int J Cancer· May 2018

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Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Gretchen Poortinga

Blood· May 2017

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Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.
Marcus Lefebure, Richard W Tothill, Elizabeth Kruse, Edwin D Hawkins, Jake Shortt, Gretchen Poortinga

Nat Commun· March 2017

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Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga

PLoS Negl Trop Dis· March 2017

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Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth.
Linna Guo, Olga Zaysteva, Zuqin Nie, Naomi C Mitchell, Jue Er Amanda Lee, Gretchen Poortinga

Nucleic Acids Res· September 2016

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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Gretchen Poortinga

Oncotarget· August 2016

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Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Gretchen Poortinga

Cancer Discov· January 2016

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S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
Naomi C Mitchell, Elissaveta B Tchoubrieva, Arjun Chahal, Simone Woods, Amanda Lee, Gretchen Poortinga

Cell Signal· October 2015

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Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
Jue Er Amanda Lee, Naomi C Mitchell, Olga Zaytseva, Arjun Chahal, Peter Mendis, Gretchen Poortinga

Nat Commun· June 2015

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A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Elaine Sanij, Jeannine Diesch, Analia Lesmana, Gretchen Poortinga, Nadine Hein

Genome Res· February 2015

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The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.
Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots

Cancer Discov· January 2013

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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck

Cancer Cell· July 2012

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AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
Joanna C Chan, Katherine M Hannan, Kim Riddell, Pui Yee Ng, Abigail Peck, Gretchen Poortinga

Sci Signal· August 2011

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c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation.
Gretchen Poortinga, Meaghan Wall, Elaine Sanij, Kasia Siwicki, Jason Ellul

Nucleic Acids Res· April 2011

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UBF levels determine the number of active ribosomal RNA genes in mammals.
Elaine Sanij, Gretchen Poortinga, Kerith Sharkey, Sandy Hung, Timothy P Holloway

J Cell Biol· December 2008

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Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation.
Meaghan Wall, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan

Blood· September 2008

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