Publications by authors named "Keefe T Chan"

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Correction: INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors.
Catherine Dietrich, Alec Trub, Antonio Ahn, Michael Taylor, Krutika Ambani, Keefe T Chan

Cancer Discov· October 2025

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Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer.
Carmelo Cerra, Madeleine R C Tancock, Niko Thio, Ada Koo, AnnRann Wong, Keefe T Chan

Cell Death Discov· September 2025

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INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors.
Catherine Dietrich, Alec Trub, Antonio Ahn, Michael Taylor, Krutika Ambani, Keefe T Chan

Cancer Discov· March 2024

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Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation.
Haoran Zhu, Keefe T Chan, Xinran Huang, Carmelo Cerra, Shaun Blake

Elife· June 2022

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Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy.
Jian Kang, Natalie Brajanovski, Keefe T Chan, Jiachen Xuan, Richard B Pearson

Signal Transduct Target Ther· August 2021

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The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine R C Tancock, Piyush B Madhamshettiwar, Keefe T Chan

Br J Cancer· February 2021

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Keefe T Chan

EMBO J· November 2020

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Keefe T Chan

Nat Commun· May 2020

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Oncogene-induced senescence: From biology to therapy.
Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan

Mech Ageing Dev· April 2020

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A functional genetic screen defines the AKT-induced senescence signaling network.
Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos

Cell Death Differ· February 2020

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Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Keefe T Chan

Proc Natl Acad Sci U S A· September 2019

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Cystathionine -Synthase in Physiology and Cancer.
Haoran Zhu, Shaun Blake, Keefe T Chan, Richard B Pearson, Jian Kang

Biomed Res Int· January 2019

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The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.
Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M Hannan, Ross D Hannan, Keefe T Chan

Int J Mol Sci· January 2017

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Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.
Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan

Assay Drug Dev Technol· September 2016

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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch

Oncotarget· August 2016

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β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
Sarah J Creed, Caroline P Le, Mona Hassan, Cindy K Pon, Sabine Albold, Keefe T Chan

Breast Cancer Res· November 2015

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IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.
Craig C Carson, Stergios J Moschos, Sharon N Edmiston, David B Darr, Nana Nikolaishvili-Feinberg, Keefe T Chan

Clin Cancer Res· May 2015

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LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.
Keefe T Chan, Sreeja B Asokan, Samantha J King, Tao Bo, Evan S Dubose

J Cell Biol· October 2014

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Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin.
Keefe T Chan, Stephen W Jones, Hailey E Brighton, Tao Bo, Shelly D Cochran

Intravital· April 2013

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LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Wenjin Liu, Kimberly B Monahan, Adam D Pfefferle, Takeshi Shimamura, Jessica Sorrentino, Keefe T Chan

Cancer Cell· June 2012

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Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.
Keefe T Chan, David W Roadcap, Nicholas Holoweckyj, James E Bear

Biochem J· May 2012

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Unraveling the enigma: progress towards understanding the coronin family of actin regulators.
Keefe T Chan, Sarah J Creed, James E Bear

Trends Cell Biol· August 2011

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Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).
Keefe T Chan, David A Bennin, Anna Huttenlocher

J Biol Chem· April 2010

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FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
Keefe T Chan, Christa L Cortesio, Anna Huttenlocher

J Cell Biol· April 2009

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Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
Christa L Cortesio, Keefe T Chan, Benjamin J Perrin, Nicholas O Burton, Sheng Zhang

J Cell Biol· March 2008

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