Publications by authors named "Adam D Pfefferle"

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Identifying locally recurrent versus second primary breast cancer: Genomic versus clinical criteria from Carolina Breast Cancer Study Phase III.
Sarah C Van Alsten, Michael I Love, Benjamin C Calhoun, Eboneé N Butler, Adam D Pfefferle

Cancer Epidemiol Biomarkers Prev· December 2025

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Racial differences in endometrial cancer genomics and outcomes using UNCseq targeted DNA sequencing.
Meredith A Newton, Jason D Merker, Weida Gong, Sushant Patil, Xianming Tan, Adam D Pfefferle

Gynecol Oncol Rep· August 2025

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Transcriptomic Predictors of Survival for Palbociclib + Endocrine Therapy Versus Capecitabine in Aromatase Inhibitor-Resistant Breast Cancer From the GEICAM/2013-02 PEARL Trial.
Yash N Agrawal, Aranzazu Fernández-Martínez, Miguel Gil-Gil, Christoph Zielinski, Manuel Ruiz-Borrego, Adam D Pfefferle

JCO Precis Oncol· July 2025

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A randomized phase II/III study of paclitaxel/carboplatin/metformin versus paclitaxel/carboplatin/placebo as initial therapy for measurable stage III or IVA, stage IVB, or recurrent endometrial cancer: An NRG oncology/GOG study.
Victoria L Bae-Jump, Michael W Sill, Paola A Gehrig, Jason D Merker, David L Corcoran, Adam D Pfefferle

Gynecol Oncol· April 2025

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Prognostic and molecular multi-platform analysis of CALGB 40603 (Alliance) and public triple-negative breast cancer datasets.
Brooke M Felsheim, Aranzazu Fernandez-Martinez, Cheng Fan, Adam D Pfefferle, Michele C Hayward

NPJ Breast Cancer· March 2025

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Cell-cycle inhibition and immune microenvironment in breast cancer treated with ribociclib and letrozole or chemotherapy.
Tomás Pascual, Aranzazu Fernandez-Martinez, Yash Agrawal, Adam D Pfefferle, Nuria Chic

NPJ Breast Cancer· March 2024

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Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer.
Narmeen S Rashid, David C Boyd, Amy L Olex, Jacqueline M Grible, Alex K Duong, Adam D Pfefferle

Sci Rep· December 2022

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Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells.
Patrick D Rädler, Barbara L Wehde, Aleata A Triplett, Hridaya Shrestha, Jonathan H Shepherd, Adam D Pfefferle

Nat Commun· June 2021

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The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.
Adam D Pfefferle, David B Darr, Benjamin C Calhoun, Kevin R Mott, Jeffrey M Rosen

Dis Model Mech· July 2019

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A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Daniel P Hollern, Cristina M Contreras, Stephanie Dance-Barnes, Grace O Silva, Adam D Pfefferle

Breast Cancer Res Treat· February 2019

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Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.
Adam D Pfefferle, Yash N Agrawal, Daniel C Koboldt, Krishna L Kanchi, Jason I Herschkowitz

Dis Model Mech· July 2016

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Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.
Jerry Usary, David Brian Darr, Adam D Pfefferle, Charles M Perou

Curr Protoc Pharmacol· March 2016

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c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression.
Michael A Cantrell, Nancy D Ebelt, Adam D Pfefferle, Charles M Perou, Carla Lynn Van Den Berg

Oncotarget· May 2015

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Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy.
Adam D Pfefferle, Benjamin T Spike, Geoff M Wahl, Charles M Perou

Breast Cancer Res Treat· January 2015

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Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis.
J Chuck Harrell, Adam D Pfefferle, Nicole Zalles, Aleix Prat, Cheng Fan

Clin Exp Metastasis· January 2014

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Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.
Adam D Pfefferle, Jason I Herschkowitz, Jerry Usary, Joshua Chuck Harrell, Benjamin T Spike

Genome Biol· November 2013

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Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.
Ariella B Hanker, Adam D Pfefferle, Justin M Balko, María Gabriela Kuba, Christian D Young

Proc Natl Acad Sci U S A· August 2013

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Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Christian D Young, Adam D Pfefferle, Philip Owens, María G Kuba, Brent N Rexer

Cancer Res· July 2013

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Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.
Marsha D Wallace, Adam D Pfefferle, Lishuang Shen, Adrian J McNairn, Ethan G Cerami

Genetics· October 2012

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Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models.
Patrick J Roberts, Jerry E Usary, David B Darr, Patrick M Dillon, Adam D Pfefferle

Clin Cancer Res· October 2012

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Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation.
Jessica E Hutti, Adam D Pfefferle, Sean C Russell, Mayukh Sircar, Charles M Perou

Cancer Res· July 2012

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LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Wenjin Liu, Kimberly B Monahan, Adam D Pfefferle, Takeshi Shimamura, Jessica Sorrentino

Cancer Cell· June 2012

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A potential role for glucose transporters in the evolution of human brain size.
Olivier Fedrigo, Adam D Pfefferle, Courtney C Babbitt, Ralph Haygood, Christine E Wall

Brain Behav Evol· February 2012

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Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution.
Adam D Pfefferle, Lisa R Warner, Catrina W Wang, William J Nielsen, Courtney C Babbitt

J Hum Evol· February 2011

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A pipeline to determine RT-QPCR control genes for evolutionary studies: application to primate gene expression across multiple tissues.
Olivier Fedrigo, Lisa R Warner, Adam D Pfefferle, Courtney C Babbitt, Peter Cruz-Gordillo

PLoS One· September 2010

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