Publications by authors named "Guy Bemis"

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Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
Tiansheng Wang, Guy Bemis, Brian Hanzelka, Harmon Zuccola, Michael Wynn

ACS Med Chem Lett· December 2017

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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
John P Duffy, Edmund M Harrington, Francesco G Salituro, John E Cochran, Jeremy Green, Guy W Bemis

ACS Med Chem Lett· October 2011

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Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.
Sladjana Prisic, Selasi Dankwa, Daniel Schwartz, Michael F Chou, Jason W Locasale, Guy Bemis

Proc Natl Acad Sci U S A· April 2010

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Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
Alex M Aronov, Qing Tang, Gabriel Martinez-Botella, Guy W Bemis, Jingrong Cao

J Med Chem· October 2009

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4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.
Upul Bandarage, Brian Hare, Jonathan Parsons, Ly Pham, Craig Marhefka, Guy Bemis

Bioorg Med Chem Lett· September 2009

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Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase.
Ron Grey, Albert C Pierce, Guy W Bemis, Marc D Jacobs, Cameron Stuver Moody

Bioorg Med Chem Lett· June 2009

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Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.
Jingrong Cao, Huai Gao, Guy Bemis, Francesco Salituro, Mark Ledeboer

Bioorg Med Chem Lett· May 2009

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Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Luc J Farmer, Guy Bemis, Shawn D Britt, John Cochran, Martin Connors

Bioorg Med Chem Lett· December 2008

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Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.
Alex M Aronov, Christopher Baker, Guy W Bemis, Jingrong Cao, Guanjing Chen

J Med Chem· March 2007

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A minimalist approach to fragment-based ligand design using common rings and linkers: application to kinase inhibitors.
Alex M Aronov, Guy W Bemis

Proteins· October 2004

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CORES: an automated method for generating three-dimensional models of protein/ligand complexes.
Brian J Hare, W Patrick Walters, Paul R Caron, Guy W Bemis

J Med Chem· September 2004

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BREED: Generating novel inhibitors through hybridization of known ligands. Application to CDK2, p38, and HIV protease.
Albert C Pierce, Govinda Rao, Guy W Bemis

J Med Chem· May 2004

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Kinase inhibitors and the case for CH...O hydrogen bonds in protein-ligand binding.
Albert C Pierce, Kathryn L Sandretto, Guy W Bemis

Proteins· December 2002

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