Publications by authors named "Marc D Jacobs"

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ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
Huai Gao, Craig Marhefka, Marc D Jacobs, Jingrong Cao, Upul K Bandarage

Bioorg Med Chem Lett· August 2018

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ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
Upul K Bandarage, Jingrong Cao, Jon H Come, John J Court, Huai Gao, Marc D Jacobs

Bioorg Med Chem Lett· August 2018

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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
Jon H Come, Philip N Collier, James A Henderson, Albert C Pierce, Robert J Davies, Marc D Jacobs

J Med Chem· June 2018

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Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2.
Luc J Farmer, Michael P Clark, Michael J Boyd, Emanuele Perola, Steven M Jones, Marc D Jacobs

ACS Med Chem Lett· February 2017

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Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
Upul K Bandarage, Michael P Clark, Emanuele Perola, Huai Gao, Marc D Jacobs

ACS Med Chem Lett· February 2017

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Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis.
Joseph Cursons, Catherine E Angel, Daniel G Hurley, Cristin G Print, P Rod Dunbar, Marc D Jacobs

Gigascience· July 2016

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Regulation of ERK-MAPK signaling in human epidermis.
Joseph Cursons, Jerry Gao, Daniel G Hurley, Cristin G Print, P Rod Dunbar, Marc D Jacobs

BMC Syst Biol· July 2015

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Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit.
Randal A Byrn, Steven M Jones, Hamilton B Bennett, Chris Bral, Michael P Clark, Marc D Jacobs

Antimicrob Agents Chemother· March 2015

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Development of a 3D finite element model of lens microcirculation.
Ehsan Vaghefi, Duane T K Malcolm, Marc D Jacobs, Paul J Donaldson

Biomed Eng Online· September 2012

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Magnetic resonance and confocal imaging of solute penetration into the lens reveals a zone of restricted extracellular space diffusion.
Ehsan Vaghefi, Kerry Walker, Beau P Pontre, Marc D Jacobs, Paul J Donaldson

Am J Physiol Regul Integr Comp Physiol· June 2012

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Visualizing ocular lens fluid dynamics using MRI: manipulation of steady state water content and water fluxes.
Ehsan Vaghefi, Beau P Pontre, Marc D Jacobs, Paul J Donaldson

Am J Physiol Regul Integr Comp Physiol· August 2011

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Inference of an in situ epidermal intracellular signaling cascade.
Joseph Cursons, Daniel Hurley, Catherine E Angel, Rod Dunbar, Edmund J Crampin, Marc D Jacobs

Annu Int Conf IEEE Eng Med Biol Soc· March 2011

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Multiscale systems integration in the eye.
Marc D Jacobs

Wiley Interdiscip Rev Syst Biol Med· December 2010

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Visualization of transverse diffusion paths across fiber cells of the ocular lens by small animal MRI.
Ehsan Vaghefi, Beau Pontre, Paul J Donaldson, Peter J Hunter, Marc D Jacobs

Physiol Meas· October 2009

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Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase.
Ron Grey, Albert C Pierce, Guy W Bemis, Marc D Jacobs, Cameron Stuver Moody

Bioorg Med Chem Lett· June 2009

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Uptake and distribution of gadolinium in the ocular lens.
Ehsan Vaghefi, Marc D Jacobs

Annu Int Conf IEEE Eng Med Biol Soc· May 2009

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ROCK enzymatic assay.
John D Doran, Marc D Jacobs

Methods Mol Biol· January 2009

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Differentiation-dependent modification and subcellular distribution of aquaporin-0 suggests multiple functional roles in the rat lens.
Angus C Grey, Ling Li, Marc D Jacobs, Kevin L Schey, Paul J Donaldson

Differentiation· January 2009

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Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: structure of lck/imatinib complex.
Marc D Jacobs, Paul R Caron, Brian J Hare

Proteins· March 2008

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Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core.
Julie Lim, Ling Li, Marc D Jacobs, Joerg Kistler, Paul J Donaldson

Invest Ophthalmol Vis Sci· November 2007

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Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core.
Ling Li, Julie Lim, Marc D Jacobs, Joerg Kistler, Paul J Donaldson

Invest Ophthalmol Vis Sci· March 2007

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Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Marc D Jacobs, James Black, Olga Futer, Lora Swenson, Brian Hare

J Biol Chem· April 2005

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Functional imaging: new views on lens structure and function.
Paul J Donaldson, Angus C Grey, B Rachelle Merriman-Smith, Aran M G Sisley, Christian Soeller, Marc D Jacobs

Clin Exp Pharmacol Physiol· December 2004

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Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens.
Marc D Jacobs, Christian Soeller, Aran M G Sisley, Mark B Cannell, Paul J Donaldson

Invest Ophthalmol Vis Sci· January 2004

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Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.
Angus C Grey, Marc D Jacobs, Tamir Gonen, Joerg Kistler, Paul J Donaldson

Exp Eye Res· November 2003

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