Publications by authors named "Lora Swenson"

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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
Luc J Farmer, Mark W Ledeboer, Thomas Hoock, Michael J Arnost, Randy S Bethiel, Lora Swenson

J Med Chem· September 2015

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Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.
Ernst ter Haar, Christopher M Koth, Norzehan Abdul-Manan, Lora Swenson, Joyce T Coll

Structure· September 2010

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2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.
Mark W Ledeboer, Albert C Pierce, John P Duffy, Huai Gao, David Messersmith, Lora Swenson

Bioorg Med Chem Lett· December 2009

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Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
Paul S Charifson, Anne-Laure Grillot, Trudy H Grossman, Jonathan D Parsons, Michael Badia, Lora L Swenson

J Med Chem· September 2008

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Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.
Yi Zhou, Doug J Bartels, Brian L Hanzelka, Ute Müh, Yunyi Wei, Lora Swenson

Antimicrob Agents Chemother· January 2008

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Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
Yi Zhou, Ute Müh, Brian L Hanzelka, Doug J Bartels, Yunyi Wei, Lora Swenson

J Biol Chem· August 2007

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The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Marc Jacobs, Koto Hayakawa, Lora Swenson, Steven Bellon, Mark Fleming

J Biol Chem· January 2006

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Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Marc D Jacobs, James Black, Olga Futer, Lora Swenson, Brian Hare

J Biol Chem· April 2005

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Structure of the CoA transferase from pig heart to 1.7 A resolution.
Abbie M Coros, Lora Swenson, William T Wolodko, Marie E Fraser

Acta Crystallogr D Biol Crystallogr· October 2004

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Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Steven Bellon, Jonathan D Parsons, Yunyi Wei, Koto Hayakawa, Lora L Swenson

Antimicrob Agents Chemother· May 2004

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
James Griffith, James Black, Carlos Faerman, Lora Swenson, Michael Wynn

Mol Cell· January 2004

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Crystal structure of aurora-2, an oncogenic serine/threonine kinase.
Graham M T Cheetham, Ronald M A Knegtel, Joyce T Coll, Suzanne B Renwick, Lora Swenson

J Biol Chem· November 2002

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Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.
Wuyi Meng, Lora L Swenson, Matthew J Fitzgibbon, Koto Hayakawa, Ernst Ter Haar

J Biol Chem· October 2002

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