Publications by authors named "Hans C van Leeuwen"

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P4PP: A Universal Shotgun Proteomics Data Analysis Pipeline for Virus Identification.
Armand Paauw, Evgeni Levin, Ingrid A I Voskamp-Visser, Ilka M F Marissen, Vincent Ramisse, Hans C van Leeuwen

Mol Cell Proteomics· July 2025

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A TdT-driven amplification loop increases CRISPR-Cas12a DNA detection levels.
Jordy T Zwerus, Nicole F Berghuis, Jeroen M Jacques, Roos Mars-Groenendijk, Ruud W Busker, Hans C van Leeuwen

Biosens Bioelectron· October 2024

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In-Depth Specificity Profiling of Endopeptidases Using Dedicated Mix-and-Split Synthetic Peptide Libraries and Mass Spectrometry.
Bart Claushuis, Robert A Cordfunke, Arnoud H de Ru, Annemarie Otte, Hans C van Leeuwen

Anal Chem· August 2023

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Expression of virulence and antimicrobial related proteins in Burkholderia mallei and Burkholderia pseudomallei.
Armand Paauw, Holger C Scholz, Roos H Mars-Groenendijk, Lennard J M Dekker, Theo M Luider, Hans C van Leeuwen

PLoS Negl Trop Dis· January 2023

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Combining CRISPR-Cas12a with terminal deoxynucleotidyl transferase dependent reporter elongation for pathogen detection using lateral flow test strips.
Nicole F Berghuis, Roos Mars-Groenendijk, Ruud W Busker, Armand Paauw, Hans C van Leeuwen

Biol Methods Protoc· July 2022

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Phylogenetic analysis of the bacterial Pro-Pro-endopeptidase domain reveals a diverse family including secreted and membrane anchored proteins.
Hans C van Leeuwen, Dick Roelofs, Jeroen Corver, Paul Hensbergen

Curr Res Microb Sci· December 2021

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Immobilized Regenerable Active Chlorine within a Zirconium-Based MOF Textile Composite to Eliminate Biological and Chemical Threats.
Yuk Ha Cheung, Kaikai Ma, Hans C van Leeuwen, Megan C Wasson, Xingjie Wang

J Am Chem Soc· October 2021

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Bright fluorescent nucleic acid detection with CRISPR-Cas12a and poly(thymine) templated copper nanoparticles.
Janna F M Bogers, Nicole F Berghuis, Ruud W Busker, Angelo van Booma, Armand Paauw, Hans C van Leeuwen

Biol Methods Protoc· October 2020

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Untargeted accurate identification of highly pathogenic bacteria directly from blood culture flasks.
Erwin M Berendsen, Evgeni Levin, René Braakman, Andrei Prodan, Hans C van Leeuwen

Int J Med Microbiol· January 2020

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Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.
Oleg I Klychnikov, Tatiana M Shamorkina, Stephen D Weeks, Hans C van Leeuwen, Jeroen Corver

J Biol Chem· July 2018

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Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.
Frank Fleurbaaij, Alex A Henneman, Jeroen Corver, Cornelis W Knetsch, Wiep Klaas Smits, Hans C van Leeuwen

Sci Rep· May 2018

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Covalent attachment and Pro-Pro endopeptidase (PPEP-1)-mediated release of Clostridium difficile cell surface proteins involved in adhesion.
Jeroen Corver, Valentina Cordo', Hans C van Leeuwen, Oleg I Klychnikov, Paul J Hensbergen

Mol Microbiol· September 2017

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A Novel Fic (Filamentation Induced by cAMP) Protein from Clostridium difficile Reveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism.
Emil Dedic, Husam Alsarraf, Ditte Hededam Welner, Ole Østergaard, Oleg I Klychnikov, Hans C van Leeuwen

J Biol Chem· June 2016

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Typing Pseudomonas aeruginosa Isolates with Ultrahigh Resolution MALDI-FTICR Mass Spectrometry.
Frank Fleurbaaij, Margriet E M Kraakman, Eric C J Claas, Cornelis W Knetsch, Hans C van Leeuwen

Anal Chem· June 2016

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Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831.
Paul J Hensbergen, Oleg I Klychnikov, Dennis Bakker, Irina Dragan, Michelle L Kelly, Hans C van Leeuwen

FEBS Lett· December 2015

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Clostridium difficile sortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation.
Hans C van Leeuwen, Oleg I Klychnikov, Mica A C Menks, Ed J Kuijper, Jan W Drijfhout

FEBS Lett· November 2014

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Capillary-electrophoresis mass spectrometry for the detection of carbapenemases in (multi-)drug-resistant Gram-negative bacteria.
Frank Fleurbaaij, Anthonius A M Heemskerk, Anne Russcher, Oleg I Klychnikov, André M Deelder, Hans C van Leeuwen

Anal Chem· September 2014

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Protein expression, characterization, crystallization and preliminary X-ray crystallographic analysis of a Fic protein from Clostridium difficile.
Ditte Welner, Emil Dedic, Hans C van Leeuwen, Ed Kuijper, Morten Jannik Bjerrum

Acta Crystallogr F Struct Biol Commun· June 2014

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A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.
Paul J Hensbergen, Oleg I Klychnikov, Dennis Bakker, Vincent J C van Winden, Nienke Ras, Hans C van Leeuwen

Mol Cell Proteomics· May 2014

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Clostridium difficile TcdC protein binds four-stranded G-quadruplex structures.
Hans C van Leeuwen, Dennis Bakker, Philip Steindel, Ed J Kuijper, Jeroen Corver

Nucleic Acids Res· February 2013

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Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages.
Cornelis W Knetsch, Elisabeth M Terveer, Chris Lauber, Alexander E Gorbalenya, Céline Harmanus, Hans C van Leeuwen

Infect Genet Evol· October 2012

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Analysis of a Clostridium difficile PCR ribotype 078 100 kilobase island reveals the presence of a novel transposon, Tn6164.
Jeroen Corver, Dennis Bakker, Michael S M Brouwer, Céline Harmanus, Marjolein P Hensgens, Hans C van Leeuwen

BMC Microbiol· July 2012

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The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity.
Anne M van der Does, Paul J Hensbergen, Sylvia J Bogaards, Medine Cansoy, André M Deelder, Hans C van Leeuwen

J Immunol· May 2012

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Genetic markers for Clostridium difficile lineages linked to hypervirulence.
Cornelis W Knetsch, Marjolein P M Hensgens, Céline Harmanus, Madelon W van der Bijl, Paul H M Savelkoul, Hans C van Leeuwen

Microbiology (Reading)· November 2011

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Structural and functional analysis of the TAP-inhibiting UL49.5 proteins of varicelloviruses.
Marieke C Verweij, Andrea D Lipińska, Danijela Koppers-Lalic, Edwin Quinten, Jessica Funke, Hans C van Leeuwen

Mol Immunol· September 2011

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