Publications by authors named "Stephen D Weeks"

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Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides.
Luping Pang, Stijn Lenders, Evgenii M Osipov, Stephen D Weeks, Jef Rozenski

Int J Mol Sci· December 2022

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Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors.
Evgenii M Osipov, Ali H Munawar, Steven Beelen, Daren Fearon, Alice Douangamath, Stephen D Weeks

RSC Chem Biol· August 2022

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Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Luping Pang, Vladimir Zanki, Sergei V Strelkov, Arthur Van Aerschot, Ita Gruic-Sovulj, Stephen D Weeks

Commun Biol· August 2022

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Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Luping Pang, Stephen D Weeks, Martin Juhás, Sergei V Strelkov, Jan Zitko

Int J Mol Sci· July 2021

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The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication.
Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O'Connell, Simon Bergqvist, Stephen D Weeks

Sci Rep· March 2021

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Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Dries De Ruysscher, Luping Pang, Stijn M G Lenders, Davie Cappoen, Paul Cos, Stephen D Weeks

Eur J Med Chem· February 2021

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Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery.
Luping Pang, Stephen D Weeks, Arthur Van Aerschot

Int J Mol Sci· February 2021

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Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Stephen D Weeks

Molecules· October 2020

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Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase.
Bharat Gadakh, Gaston Vondenhoff, Luping Pang, Manesh Nautiyal, Steff De Graef, Stephen D Weeks

Bioorg Med Chem· September 2020

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Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase.
Dries De Ruysscher, Luping Pang, Charles-Alexandre Mattelaer, Manesh Nautiyal, Steff De Graef, Stephen D Weeks

Bioorg Med Chem· August 2020

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Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
Machteld Sillen, Stephen D Weeks, Sergei V Strelkov, Paul J Declerck

Int J Mol Sci· August 2020

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Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
Machteld Sillen, Stephen D Weeks, Xiaohua Zhou, Andrey A Komissarov, Galina Florova

J Thromb Haemost· March 2020

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Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Valentina Zorzini, Stephen D Weeks

ACS Chem Biol· February 2020

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Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.
Michiel Vanmeert, Jamoliddin Razzokov, Muhammad Usman Mirza, Stephen D Weeks, Guy Schepers

Nucleic Acids Res· December 2019

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Structural insights into the activity and regulation of human Josephin-2.
Kimberly C Grasty, Stephen D Weeks, Patrick J Loll

J Struct Biol X· August 2019

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Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Manesh Nautiyal, Steff De Graef, Luping Pang, Bharat Gadakh, Sergei V Strelkov, Stephen D Weeks

Eur J Med Chem· July 2019

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Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
Dries De Ruysscher, Luping Pang, Steff De Graef, Manesh Nautiyal, Wim M De Borggraeve, Stephen D Weeks

Eur J Med Chem· July 2019

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Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.
Michiel Vanmeert, Jamoliddin Razzokov, Muhammad Usman Mirza, Stephen D Weeks, Guy Schepers

Nucleic Acids Res· July 2019

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Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.
Oleg I Klychnikov, Tatiana M Shamorkina, Stephen D Weeks, Hans C van Leeuwen, Jeroen Corver

J Biol Chem· July 2018

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The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8.
Vladislav M Shatov, Stephen D Weeks, Sergei V Strelkov, Nikolai B Gusev

Int J Mol Sci· July 2018

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Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases.
Baole Zhang, Steff De Graef, Manesh Nautiyal, Luping Pang, Bharat Gadakh, Stephen D Weeks

Eur J Med Chem· March 2018

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Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases.
Stephen D Weeks, Lydia K Muranova, Michelle Heirbaut, Steven Beelen, Sergei V Strelkov

Sci Rep· January 2018

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Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1.
Michelle Heirbaut, Frederik Lermyte, Esther M Martin, Steven Beelen, Frank Sobott, Stephen D Weeks

J Biol Chem· June 2017

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Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Nikolai N Sluchanko, Steven Beelen, Alexandra A Kulikova, Stephen D Weeks, Alfred A Antson

Structure· February 2017

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The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain.
Michelle Heirbaut, Frederik Lermyte, Esther M Martin, Steven Beelen, Tim Verschueren, Stephen D Weeks

Arch Biochem Biophys· November 2016

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