Publications by authors named "Jan Zitko"

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Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N'-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives.
Priam-Amedeo Houngbedji, Daria Elżbieta Nawrot, Ondřej Janďourek, Klára Konečná, Martin Novák, Jan Zitko

ChemMedChem· September 2025

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A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant acinetobacter baumannii.
Adéla Diepoltová, Daria Elzbieta Nawrot, Ondřej Janďourek, Martin Juhás, Pavel Bárta, Jan Zitko

Med Microbiol Immunol· September 2025

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Novel Quinazolinones Active against Multidrug-Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin-Binding Protein 1A as a Potential Target.
Marek Kerda, Daria Nawrot, Petr Šlechta, Miroslav Domanský, Asal Askari, Jan Zitko

ChemMedChem· July 2025

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The discovery of a new nonbile acid modulator of Takeda G protein-coupled receptor 5: An integrated computational approach.
Rudy Salam, Michael Bakker, Mária Krutáková, Alžbeta Štefela, Petr Pávek, Jan Zitko

Arch Pharm (Weinheim)· January 2025

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Antimicrobial and Antiproliferative Properties of 2-Phenyl-N-(Pyridin-2-yl)acetamides.
Daria Nawrot, Barbora Koutníková, Ondřej Janďourek, Klára Konečná, Martin Novák, Jan Zitko

Chem Biol Drug Des· January 2025

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A hit expansion of 3-benzamidopyrazine-2-carboxamide: Toward inhibitors of prolyl-tRNA synthetase with antimycobacterial activity.
Vinod Sukanth Kumar Pallabothula, Nechirwan Taimur Abdalrahman, Matteo Mori, Amir Hossein Fekri, Ondřej Janďourek, Jan Zitko

Arch Pharm (Weinheim)· August 2024

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Antimycobacterial pyridine carboxamides: From design to in vivo activity.
Daria Elżbieta Nawrot, Ghada Bouz, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Jan Zitko

Eur J Med Chem· October 2023

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-Pyrazinylhydroxybenzamides as biologically active compounds: a hit-expansion study and antimicrobial evaluation.
Marek Kerda, Petr Šlechta, Ondrej Jand'ourek, Klara Konečná, Paulina Hatoková, Jan Zitko

Future Med Chem· October 2023

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Correction to "Hybridization Approach Toward Novel Antituberculars: Design, Synthesis, and Biological Evaluation of Compounds Combining Pyrazinamide and 4-Aminosalicylic Acid".
Ghada Bouz, Petr Šlechta, Ondřej Jand'ourek, Klára Konečná, Pavla Paterová, Jan Zitko

ACS Infect Dis· August 2023

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Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. 2022, , 580.
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Jan Zitko

Pharmaceuticals (Basel)· March 2023

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Hybridization Approach Toward Novel Antituberculars: Design, Synthesis, and Biological Evaluation of Compounds Combining Pyrazinamide and 4-Aminosalicylic Acid.
Ghada Bouz, Petr Šlechta, Ondřej Jand'ourek, Klára Konečná, Pavla Paterová, Jan Zitko

ACS Infect Dis· January 2023

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Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity.
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Jan Zitko

Biomolecules· October 2022

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Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole.
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Jan Zitko

Pharmaceuticals (Basel)· May 2022

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Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl)pyrazine-2-carboxamides as inhibitors of mycobacterial methionine aminopeptidase 1.
Martin Juhás, Vinod S K Pallabothula, Katarina Grabrijan, Martina Šimovičová, Ondřej Janďourek, Jan Zitko

Bioorg Chem· January 2022

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Synthesis, Biological Evaluation, and In Silico Modeling of -Substituted Quinoxaline-2-Carboxamides.
Ghada Bouz, Sarah Bouz, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jan Zitko

Pharmaceuticals (Basel)· August 2021

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Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Luping Pang, Stephen D Weeks, Martin Juhás, Sergei V Strelkov, Jan Zitko

Int J Mol Sci· July 2021

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Inhibitors of aminoacyl-tRNA synthetases as antimycobacterial compounds: An up-to-date review.
Ghada Bouz, Jan Zitko

Bioorg Chem· May 2021

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N-pyridinylbenzamides: an isosteric approach towards new antimycobacterial compounds.
Daria Nawrot, Eliška Suchánková, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jan Zitko

Chem Biol Drug Des· March 2021

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Molecular Interactions of Pyrazine-Based Compounds to Proteins.
Martin Juhás, Jan Zitko

J Med Chem· September 2020

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-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents-The Synthesis and Biological Evaluation of Enantiomers.
Martin Juhás, Lucie Kučerová, Ondřej Horáček, Ondřej Janďourek, Vladimír Kubíček, Jan Zitko

Molecules· March 2020

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5-Alkylamino--phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation.
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Jan Zitko

Molecules· March 2020

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Exploring the detailed spectroscopic characteristics, chemical and biological activity of two cyanopyrazine-2-carboxamide derivatives using experimental and theoretical tools.
Shargina Beegum, Y Sheena Mary, Y Shyma Mary, Renjith Thomas, Stevan Armaković, Jan Zitko

Spectrochim Acta A Mol Biomol Spectrosc· January 2020

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Substituted -(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies.
Ghada Bouz, Martin Juhás, Lluis Pausas Otero, Cristina Paredes de la Red, Ondřej Janďourek, Jan Zitko

Molecules· December 2019

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Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity.
Ghada Bouz, Lucia Semelková, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Jan Zitko

Molecules· March 2019

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Design, Synthesis and Evaluation of -pyrazinylbenzamides as Potential Antimycobacterial Agents.
Jan Zitko, Alžběta Mindlová, Ondřej Valášek, Ondřej Jand'ourek, Pavla Paterová

Molecules· September 2018

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