Publications by authors named "Harold Kohn"

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Translational Stroke Research: Vision and Opportunities.
Francesca Bosetti, James I Koenig, Cenk Ayata, Stephen A Back, Kyra Becker, Harold Kohn

Stroke· September 2017

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H. Steve White: A Champion for Contemporary Epilepsy Research.
Harold Kohn

Neurochem Res· July 2017

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Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Robert Torregrosa, Xiao-Fang Yang, Erik T Dustrude, Theodore R Cummins, Rajesh Khanna, Harold Kohn

Bioorg Med Chem· July 2015

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Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide.
Ki Duk Park, Xiao-Fang Yang, Erik T Dustrude, Yuying Wang, Matthew S Ripsch, Harold Kohn

ACS Chem Neurosci· February 2015

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Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.
Hyosung Lee, Ki Duk Park, Robert Torregrosa, Xiao-Fang Yang, Erik T Dustrude, Harold Kohn

J Med Chem· July 2014

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A mentoring program to help junior faculty members achieve scholarship success.
Harold Kohn

Am J Pharm Educ· March 2014

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Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity.
Hyosung Lee, Alexander S Gold, Xiao-Fang Yang, Rajesh Khanna, Harold Kohn

Bioorg Med Chem· December 2013

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(Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents.
Hyosung Lee, Ki Duk Park, Xiao-Fang Yang, Erik T Dustrude, Sarah M Wilson, Harold Kohn

J Med Chem· July 2013

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Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties.
Ki Duk Park, Xiao-Fang Yang, Hyosung Lee, Erik T Dustrude, Yuying Wang, Harold Kohn

ACS Chem Neurosci· March 2013

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Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation.
Amber M King, Xiao-Fang Yang, Yuying Wang, Erik T Dustrude, Cindy Barbosa, Harold Kohn

ACS Chem Neurosci· December 2012

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Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Pranjal K Baruah, Jason Dinsmore, Amber M King, Christophe Salomé, Marc De Ryck, Harold Kohn

Bioorg Med Chem· June 2012

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Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties.
Amber M King, Christophe Salomé, Elise Salomé-Grosjean, Marc De Ryck, Rafal Kaminski, Harold Kohn

J Med Chem· October 2011

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Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide.
Amber M King, Marc De Ryck, Rafal Kaminski, Anne Valade, James P Stables, Harold Kohn

J Med Chem· October 2011

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Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Amber M King, Christophe Salomé, Jason Dinsmore, Elise Salomé-Grosjean, Marc De Ryck, Harold Kohn

J Med Chem· July 2011

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Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ.
Ki Duk Park, Dongwook Kim, Onrapak Reamtong, Claire Eyers, Simon J Gaskell, Harold Kohn

J Am Chem Soc· July 2011

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Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain.
Yuying Wang, Sarah M Wilson, Joel M Brittain, Matthew S Ripsch, Christophe Salomé, Harold Kohn

ACS Chem Neurosci· June 2011

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Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.
Yuying Wang, Ki Duk Park, Christophe Salome, Sarah M Wilson, James P Stables, Harold Kohn

ACS Chem Neurosci· February 2011

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The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Pierre Morieux, Christophe Salomé, Ki Duk Park, James P Stables, Harold Kohn

J Med Chem· August 2010

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Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group.
Ki Duk Park, James P Stables, Rihe Liu, Harold Kohn

Org Biomol Chem· June 2010

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Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
Christophe Salomé, Elise Salomé-Grosjean, James P Stables, Harold Kohn

J Med Chem· May 2010

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Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Christophe Salomé, Elise Salomé-Grosjean, Ki Duk Park, Pierre Morieux, Robert Swendiman, Harold Kohn

J Med Chem· February 2010

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Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.
Ki Duk Park, Pierre Morieux, Christophe Salomé, Steven W Cotten, Onrapak Reamtong, Harold Kohn

J Med Chem· November 2009

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Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.
Ki Duk Park, Rihe Liu, Harold Kohn

Chem Biol· July 2009

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Nucleophilic activation of a tetra-substituted mitomycin cyclic bis-disulfide.
Sang Hyup Lee, Harold Kohn

Chem Pharm Bull (Tokyo)· February 2009

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Triphenylphosphine Dibromide: A Simple One-pot Esterification Reagent.
Christophe Salomé, Harold Kohn

Tetrahedron· January 2009

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