Publications by authors named "Harrie Boonen"

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Application of new approach methodologies for nonclinical safety assessment of drug candidates.
Mario Beilmann, Karissa Adkins, Harrie C M Boonen, Philip Hewitt, Wenyue Hu

Nat Rev Drug Discov· September 2025

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Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103.
Erhad Ascic, Mauro Marigo, Laurent David, Kjartan Frisch Herrik, Morten Grupe, Harrie C M Boonen

J Med Chem· November 2024

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Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders.
Michael G Diemar, Mathieu Vinken, Marc Teunis, Cyrille A M Krul, Francois Busquet, Harrie Boonen

Altern Lab Anim· March 2024

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The evolving role of investigative toxicology in the pharmaceutical industry.
Francois Pognan, Mario Beilmann, Harrie C M Boonen, Andreas Czich, Gordon Dear

Nat Rev Drug Discov· April 2023

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Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Mario Beilmann, Harrie Boonen, Andreas Czich, Gordon Dear, Philip Hewitt

ALTEX· August 2019

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Lipopolysaccharides, but not Angiotensin ll, lnduces Direct Pro-lnflammatory Effects in Cultured Mouse Arteries and Human Endothelial and Vascular Smooth Muscle Cells.
Emilie M Outzen, Marina Zaki, Rahila Mehryar, Bahareh Abdolalizadeh, Waseem Sajid, Harrie C M Boonen

Basic Clin Pharmacol Toxicol· April 2017

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Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries.
Martin Blædel, Anette Sams, Harrie C M Boonen, Majid Sheykhzade

Pharmacology· September 2016

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Translational value of mechanical and vasomotor properties of mouse isolated mesenteric resistance-sized arteries.
Emilie M Outzen, Marina Zaki, Bahareh Abdolalizadeh, Anette Sams, Harrie C M Boonen

Pharmacol Res Perspect· December 2015

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Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs.
Harrie C M Boonen, Sophia G Moesgaard, Malene M Birck, Berit O Christoffersen, Susanna Cirera

Pflugers Arch· December 2014

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Medicines combinations options and regulatory hurdles.
Ole J Bjerrum, Yvonne Gautam, Esben J Bjerrum, Merete Schmiegelow, Harrie C M Boonen

Eur J Pharm Sci· July 2013

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Early onset inflammation in pre-insulin-resistant diet-induced obese rats does not affect the vasoreactivity of isolated small mesenteric arteries.
Martin Blædel, Kirsten Raun, Harrie C M Boonen, Majid Sheykhzade, Anette Sams

Pharmacology· April 2013

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Effect of ageing on the passive and active tension and pharmacodynamic characteristics of rat coronary arteries: age-dependent increase in sensitivity to 5-HT and K+.
Majid Sheykhzade, Anja Hviid Simonsen, Harrie C M Boonen, Emilie M Outzen, Niels C Berg Nyborg

Pharmacology· April 2013

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Characterization of capsaicin induced responses in mice vas deferens: evidence of CGRP uptake.
Majid Sheykhzade, Saurabh Gupta, Tinne Sørensen, Ole Aabling Sørensen, Hans Koch, Harrie C M Boonen

Eur J Pharmacol· September 2011

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New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Flemming E Nielsen, Søren Ebdrup, Anette Frost Jensen, Lars Ynddal, Thora B Bodvarsdottir, Harrie C M Boonen

J Med Chem· July 2006

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Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.
Søren C Schou, Holger C Hansen, Tina M Tagmose, Harrie C M Boonen, Anne Worsaae

Bioorg Med Chem· January 2005

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Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
Tina M Tagmose, Søren C Schou, John P Mogensen, Flemming E Nielsen, Per O G Arkhammar, Harrie C M Boonen

J Med Chem· June 2004

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Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells.
Tina M Tagmose, Florencio Zaragoza, Harrie C M Boonen, Anne Worsaae, John P Mogensen

Bioorg Med Chem· March 2003

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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Flemming E Nielsen, Thora B Bodvarsdottir, Anne Worsaae, Peter MacKay, Carsten E Stidsen, Harrie C M Boonen

J Med Chem· September 2002

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