Publications by authors named "Lars Ynddal"

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Variant screening of PYY leads to potent long-acting PYY analogs with superior Y receptor selectivity.
Søren Østergaard, Carsten Jessen, Johan F Paulsson, Marina A Kasimova, Kilian W Conde-Frieboes, Lars Ynddal

Sci Transl Med· March 2025

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The effect of fatty diacid acylation of human PYY on Y receptor potency and half-life in minipigs.
Søren Østergaard, Johan F Paulsson, Jacob Kofoed, Franziska Zosel, Jørgen Olsen, Lars Ynddal

Sci Rep· October 2021

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Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
Peter Madsen, János T Kodra, Carsten Behrens, Erica Nishimura, Claus B Jeppesen, Lars Ynddal

J Med Chem· May 2009

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Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Per Sauerberg, Grith S Olsen, Lone Jeppesen, John P Mogensen, Ingrid Pettersson, Lars Ynddal

J Med Chem· April 2007

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New beta-alanine derivatives are orally available glucagon receptor antagonists.
Jesper Lau, Carsten Behrens, Ulla G Sidelmann, Lotte B Knudsen, Behrend Lundt, Lars Ynddal

J Med Chem· January 2007

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New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Flemming E Nielsen, Søren Ebdrup, Anette Frost Jensen, Lars Ynddal, Thora B Bodvarsdottir

J Med Chem· July 2006

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On-line turbulent-flow chromatography-high-performance liquid chromatography-mass spectrometry for fast sample preparation and quantitation.
Lars Ynddal, Steen Honoré Hansen

J Chromatogr A· December 2003

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Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.
Per Sauerberg, Paul S Bury, John P Mogensen, Heinz-Josef Deussen, Ingrid Pettersson, Lars Ynddal

J Med Chem· November 2003

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Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
John P Mogensen, Lone Jeppesen, Paul S Bury, Ingrid Pettersson, Jan Fleckner, Lars Ynddal

Bioorg Med Chem Lett· January 2003

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Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.
Peter Madsen, Anthony Ling, Michael Plewe, Christian K Sams, Lotte B Knudsen, Lars Ynddal

J Med Chem· December 2002

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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Flemming E Nielsen, Thora B Bodvarsdottir, Anne Worsaae, Peter MacKay, Carsten E Stidsen, Lars Ynddal

J Med Chem· September 2002

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Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Per Sauerberg, Ingrid Pettersson, Lone Jeppesen, Paul S Bury, John P Mogensen, Lars Ynddal

J Med Chem· February 2002

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