Publications by authors named "Jesper Lau"

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The Discovery and Development of Liraglutide and Semaglutide.
Lotte Bjerre Knudsen, Jesper Lau

Front Endocrinol (Lausanne)· April 2019

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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
Katrine D Galsgaard, Emilie Elmelund, Christian D Johansen, Anna B Bomholt, Hüsün S Kizilkaya, Jesper F Lau

Mol Metab· December 2022

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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells.
Emilie Elmelund, Katrine D Galsgaard, Christian D Johansen, Samuel A J Trammell, Anna B Bomholt, Jesper F Lau

iScience· November 2022

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Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls.
Lotte Simonsen, Jesper Lau, Thomas Kruse, Tingqing Guo, Jim McGuire

PLoS One· April 2022

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Investigation into reversed phase chromatography peptide separation systems part I: Development of a protocol for column characterisation.
Jennifer K Field, Melvin R Euerby, Jesper Lau, Henning Thøgersen, Patrik Petersson

J Chromatogr A· October 2019

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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.
Maria Daniela Garcia-Castillo, Daniel J-F Chinnapen, Yvonne M Te Welscher, Rodrigo J Gonzalez, Samir Softic, Jesper Lau

Elife· May 2018

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Structure of the glucagon receptor in complex with a glucagon analogue.
Haonan Zhang, Anna Qiao, Linlin Yang, Ned Van Eps, Klaus S Frederiksen, Jesper Lau

Nature· January 2018

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Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Gaojie Song, Dehua Yang, Yuxia Wang, Chris de Graaf, Qingtong Zhou, Jesper Lau

Nature· June 2017

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Structure of the full-length glucagon class B G-protein-coupled receptor.
Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Jesper Lau

Nature· June 2017

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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.
Chris de Graaf, Dan Donnelly, Denise Wootten, Jesper Lau, Patrick M Sexton, Laurence J Miller

Pharmacol Rev· October 2016

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Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1.
Cecilia Nilsson, Thomas Kruse Hansen, Christian Rosenquist, Bolette Hartmann, János T Kodra, Jesper F Lau, Trine Ryberg Clausen

Eur J Pharmacol· February 2016

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Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Jesper Lau, Paw Bloch, Lauge Schäffer, Ingrid Pettersson, Jane Spetzler

J Med Chem· September 2015

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Structure of the human glucagon class B G-protein-coupled receptor.
Fai Yiu Siu, Min He, Chris de Graaf, Gye Won Han, Dehua Yang, Jesper Lau

Nature· July 2013

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Transmembrane α-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor.
Christina Rye Underwood, Sanne Møller Knudsen, Birgitte Schjellerup Wulff, Hans Bräuner-Osborne, Jesper Lau

Pharmacology· April 2012

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Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues.
Kilian Conde-Frieboes, Henning Thøgersen, Jesper F Lau, Ulrich Sensfuss, Thomas K Hansen

J Med Chem· March 2012

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Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
Peter Madsen, János T Kodra, Carsten Behrens, Erica Nishimura, Claus B Jeppesen, Jesper Lau

J Med Chem· May 2009

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Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.
János T Kodra, Anker Steen Jørgensen, Birgitte Andersen, Carsten Behrens, Christian Lehn Brand, Claus Bekker Jeppesen, Jesper Lau

J Med Chem· September 2008

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Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.
Steffen Runge, Henning Thøgersen, Kjeld Madsen, Jesper Lau, Rainer Rudolph

J Biol Chem· April 2008

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Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.
Min Teng, Michael D Johnson, Christine Thomas, Dan Kiel, James N Lakis, Jesper Lau

Bioorg Med Chem Lett· October 2007

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Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.
Steffen Runge, Susann Schimmer, Jan Oschmann, Christine Bruun Schiødt, Sanne Möller Knudsen, Claus Bekker Jeppesen, Jesper Lau

Biochemistry· May 2007

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New beta-alanine derivatives are orally available glucagon receptor antagonists.
Jesper Lau, Carsten Behrens, Ulla G Sidelmann, Lotte B Knudsen, Behrend Lundt

J Med Chem· January 2007

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Small-molecule agonists for the glucagon-like peptide 1 receptor.
Lotte Bjerre Knudsen, Dan Kiel, Min Teng, Carsten Behrens, Dilip Bhumralkar, Claus B Jeppesen, Jesper Lau

Proc Natl Acad Sci U S A· January 2007

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Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
Jesper F Lau, Claus Bekker Jeppesen, Karin Rimvall, Rolf Hohlweg

Bioorg Med Chem Lett· October 2006

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Parallel solid-phase synthesis of disubstituted (5-biphenyltetrazolyl) hydantoins and thiohydantoins targeting the growth hormone secretagogue receptor.
Rune Severinsen, Jesper F Lau, Kent Bondensgaard, Birgit S Hansen, Mikael Begtrup

Bioorg Med Chem Lett· January 2004

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Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.
Peter Madsen, Anthony Ling, Michael Plewe, Christian K Sams, Lotte B Knudsen, Jesper Lau

J Med Chem· December 2002

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