Publications by authors named "Harrison Penrose"

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A Living Organoid Biobank of Crohn's Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes.
Harrison M Penrose, Saptarshi Sinha, Courtney Tindle, Kameron Zablan, Helen N Le

medRxiv· July 2025

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F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery.
Saptarshi Sinha, Ella McLaren, Madhubanti Mullick, Harrison M Penrose, Courtney Tindle

bioRxiv· April 2025

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Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels.
Jenisha Ghimire, Morgan E Collins, Patricia Snarski, Angelle N King, Emmanuelle Ruiz, Harrison M Penrose

Gastroenterology· February 2025

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FOXO3 Deficiency in Neutrophils Drives Colonic Inflammation and Tumorigenesis.
Jenisha Ghimire, Rida Iftikhar, Harrison M Penrose, Patricia Snarski, Emmanuelle Ruiz

Int J Mol Sci· June 2023

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The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients.
Young Su Park, Sang Bum Kang, Ronald R Marchelletta, Harrison M Penrose, Roos Ruiter-Visser

Pharmaceutics· March 2023

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Correction: Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity.
Rida Iftikhar, Harrison M Penrose, Angelle N King, Joshua S Samudre, Morgan E Collins

Oncogenesis· March 2022

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FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis.
Rida Iftikhar, Harrison M Penrose, Angelle N King, Yunah Kim, Emmanuelle Ruiz

Metabolites· March 2022

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Trends in the Incidence of Early-Onset Colorectal Adenocarcinoma Among Black and White US Residents Aged 40 to 49 Years, 2000-2017.
Eric M Montminy, Meijiao Zhou, Lauren Maniscalco, Harrison Penrose, Timothy Yen

JAMA Netw Open· November 2021

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Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity.
Rida Iftikhar, Harrison M Penrose, Angelle N King, Joshua S Samudre, Morgan E Collins

Oncogenesis· November 2021

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STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells.
Harrison M Penrose, Akemi Katsurada, Kayoko Miyata, Maki Urushihara, Ryousuke Satou

J Renin Angiotensin Aldosterone Syst· July 2021

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Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapy.
Harrison M Penrose, Rida Iftikhar, Morgan E Collins, Eman Toraih, Emmanuelle Ruiz

Sci Rep· April 2021

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Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease.
Emmanuelle Ruiz, Harrison M Penrose, Sandra Heller, Hani Nakhoul, Melody Baddoo

Gut Microbes· May 2020

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Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.
Harrison M Penrose, Chloe Cable, Sandra Heller, Nathan Ungerleider, Hani Nakhoul

Cell Mol Gastroenterol Hepatol· May 2019

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Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure.
Ryousuke Satou, Harrison Penrose, L Gabriel Navar

Curr Hypertens Rep· October 2018

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In colonic ρ (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer.
Harrison M Penrose, Sandra Heller, Chloe Cable, Hani Nakhoul, Nate Ungerleider

Oncoscience· November 2017

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Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation.
Sandra Heller, Harrison M Penrose, Chloe Cable, Debjani Biswas, Hani Nakhoul

FASEB J· May 2017

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High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors.
Harrison M Penrose, Sandra Heller, Chloe Cable, Hani Nakhoul, Melody Baddoo

Carcinogenesis· March 2017

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VSL#3 Probiotic Stimulates T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-γ-induced Intestinal Epithelial Barrier Defects.
Moorthy Krishnan, Harrison M Penrose, Nilay N Shah, Ronald R Marchelletta, Declan F McCole

Inflamm Bowel Dis· December 2016

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Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets.
Sandra Heller, Chloe Cable, Harrison Penrose, Rania Makboul, Debjani Biswas

Am J Physiol Gastrointest Liver Physiol· May 2016

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Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells.
Ryan O'Leary, Harrison Penrose, Kayoko Miyata, Ryousuke Satou

Am J Physiol Renal Physiol· May 2016

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Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.
Harrison Penrose, Sandra Heller, Chloe Cable, Rania Makboul, Gita Chadalawada

Biochem Biophys Res Commun· January 2016

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A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa.
Sang Bum Kang, Ronald R Marchelletta, Harrison Penrose, Michael J Docherty, Declan F McCole

Pharmacol Res Perspect· March 2015

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Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function.
Harrison M Penrose, Ronald R Marchelletta, Moorthy Krishnan, Declan F McCole

J Biol Chem· November 2013

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