Publications by authors named "Harry Kleanthous"

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Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2.
Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J Sheward, Harry Kleanthous

NPJ Vaccines· January 2024

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Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice.
Mohammad Suhail Khan, Virginie Jakob, Randhir Singh, Raju S Rajmani, Sahil Kumar, Harry Kleanthous

Pharmaceutics· December 2023

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Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants.
Nidhi Mittal, Sahil Kumar, Raju S Rajmani, Randhir Singh, Céline Lemoine, Harry Kleanthous

NPJ Vaccines· October 2023

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Antibody-mediated NK cell activation as a correlate of immunity against influenza infection.
Carolyn M Boudreau, John S Burke, Ashraf S Yousif, Maya Sangesland, Sandra Jastrzebski, Harry Kleanthous

Nat Commun· August 2023

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Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD).
Ozan S Kumru, Sakshi Bajoria, Kawaljit Kaur, John M Hickey, Greta Van Slyke, Harry Kleanthous

Hum Vaccin Immunother· August 2023

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Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.
Yupeng Feng, Meng Yuan, John M Powers, Mengyun Hu, Jennifer E Munt, Harry Kleanthous

Sci Transl Med· May 2023

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Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018 Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen.
Sakshi Bajoria, Ozan S Kumru, Jennifer Doering, Katherine Berman, Greta Van Slyke, Harry Kleanthous

Vaccines (Basel)· May 2023

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Effect of adjuvanting RBD-dimer-based subunit COVID-19 vaccines with Sepivac SWE™.
Senyu Xu, Huixin Duan, Yaling An, Xiyue Jin, Minrun Duan, Harry Kleanthous

Vaccine· April 2023

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Pre-existing Fc profiles shape the evolution of neutralizing antibody breadth following influenza vaccination.
Carolyn M Boudreau, John S Burke, Alexander L Roederer, Matthew J Gorman, Sophia Mundle, Harry Kleanthous

Cell Rep Med· March 2023

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Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques.
Catherine Jacob-Dolan, Jingyou Yu, Katherine McMahan, Victoria Giffin, Abishek Chandrashekar, Harry Kleanthous

NPJ Vaccines· February 2023

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Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.
Sergio A Rodriguez-Aponte, Neil C Dalvie, Ting Y Wong, Ryan S Johnston, Christopher A Naranjo, Harry Kleanthous

Vaccine· January 2023

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Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2.
Yupeng Feng, Meng Yuan, John M Powers, Mengyun Hu, Jennifer E Munt, Harry Kleanthous

bioRxiv· January 2023

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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Chengcheng Fan, Alexander A Cohen, Miso Park, Alfur Fu-Hsin Hung, Jennifer R Keeffe, Harry Kleanthous

Immunity· December 2022

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Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants.
Sakshi Bajoria, Kawaljit Kaur, Ozan S Kumru, Greta Van Slyke, Jennifer Doering, Harry Kleanthous

Hum Vaccin Immunother· November 2022

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Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine.
Prabhu S Arunachalam, Yupeng Feng, Usama Ashraf, Mengyun Hu, Alexandra C Walls, Harry Kleanthous

Sci Transl Med· August 2022

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Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice.
Lilit Grigoryan, Audrey Lee, Alexandra C Walls, Lilin Lai, Benjamin Franco, Harry Kleanthous

NPJ Vaccines· May 2022

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Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of toxin B.
Jinyu Liu, Michael Kothe, Jianxin Zhang, Eliud Oloo, Svetlana Stegalkina, Harry Kleanthous

Curr Res Struct Biol· April 2022

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SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques.
Neil C Dalvie, Lisa H Tostanoski, Sergio A Rodriguez-Aponte, Kawaljit Kaur, Sakshi Bajoria, Harry Kleanthous

Sci Adv· March 2022

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Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells.
Anouk Smet, Joao Paulo Portela Catani, Tine Ysenbaert, Amanda Gonçalves, Harry Kleanthous

PLoS One· February 2022

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Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.
Alexandra C Walls, Marcos C Miranda, Alexandra Schäfer, Minh N Pham, Allison Greaney, Harry Kleanthous

Cell· October 2021

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Scientific rationale for developing potent RBD-based vaccines targeting COVID-19.
Harry Kleanthous, Judith Maxwell Silverman, Karen W Makar, In-Kyu Yoon, Nicholas Jackson

NPJ Vaccines· October 2021

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Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.
Neil C Dalvie, Sergio A Rodriguez-Aponte, Brittany L Hartwell, Lisa H Tostanoski, Andrew M Biedermann, Harry Kleanthous

Proc Natl Acad Sci U S A· September 2021

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Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans.
Jiwon Jung, Sophia T Mundle, Irina V Ustyugova, Andrew P Horton, Daniel R Boutz, Harry Kleanthous

J Clin Invest· July 2021

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A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates.
Neil C Dalvie, Lisa H Tostanoski, Sergio A Rodriguez-Aponte, Kawaljit Kaur, Sakshi Bajoria, Harry Kleanthous

bioRxiv· July 2021

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Adjuvanting a subunit COVID-19 vaccine to induce protective immunity.
Prabhu S Arunachalam, Alexandra C Walls, Nadia Golden, Caroline Atyeo, Stephanie Fischinger, Harry Kleanthous

Nature· June 2021

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