Publications by authors named "Hayley Affronti"

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Targeting polyamine metabolism in an ex vivo prostatectomy model.
Hayley C Affronti, Aryn M Rowsam, Spencer R Rosario, Dominic J Smiraglia

Methods Enzymol· May 2025

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A feedforward loop between ACLY and MYC supports T-ALL progression in vivo.
Victoria da Silva-Diz, Amartya Singh, Maya Aleksandrova, Oekyung Kim, Christopher Thai, Hayley Affronti

Blood Neoplasia· May 2025

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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis.
Phuong T T Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T Izzo, Hayley A Affronti

Cell Rep· February 2025

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ACLY alternative splicing correlates with cancer phenotypes.
Julianna G Supplee, Hayley C Affronti, Richard Duan, Rebekah C Brooks, Zachary E Stine

J Biol Chem· July 2024

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Therapeutic targeting of ACLY in T-ALL .
Victoria da Silva-Diz, Amartya Singh, Maya Aleksandrova, Oekyung Kim, Christopher Thai, Hayley Affronti

bioRxiv· June 2024

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Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Luke T Izzo, Sophie Trefely, Christina Demetriadou, Jack M Drummond, Takuya Mizukami, Hayley Affronti

Sci Adv· May 2023

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JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy.
Spencer R Rosario, Justine J Jacobi, Mark D Long, Hayley C Affronti, Aryn M Rowsam

Mol Cancer Res· January 2023

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Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer.
Mark D Long, Justine J Jacobi, Prashant K Singh, Gerard Llimos, Sajad A Wani, Hayley C Affronti

Cell Rep· December 2021

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Lactate supports a metabolic-epigenetic link in macrophage polarization.
Jordan T Noe, Beatriz E Rendon, Anne E Geller, Lindsey R Conroy, Samantha M Morrissey, Hayley C Affronti

Sci Adv· November 2021

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Glutamine deprivation triggers NAGK-dependent hexosamine salvage.
Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji

Elife· November 2021

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Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer.
Mark D Long, Vineet K Dhiman, Hayley C Affronti, Qiang Hu, Song Liu

Sci Rep· June 2021

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The Bidirectional Relationship Between Cancer Epigenetics and Metabolism.
Luke T Izzo, Hayley C Affronti, Kathryn E Wellen

Annu Rev Cancer Biol· March 2021

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Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy.
Hayley C Affronti, Aryn M Rowsam, Anthony J Pellerite, Spencer R Rosario, Mark D Long

Nat Commun· January 2020

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Epigenetic Control of Fatty-Acid Metabolism Sustains Glioma Stem Cells.
Hayley C Affronti, Kathryn E Wellen

Cancer Discov· September 2019

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ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis.
Gleb A Bazilevsky, Hayley C Affronti, Xuepeng Wei, Sydney L Campbell, Kathryn E Wellen

J Biol Chem· May 2019

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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females.
Sully Fernandez, John M Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Hayley C Affronti

Cell Rep· May 2019

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Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney L Campbell, Robert J Norgard, Hayley C Affronti

Cancer Discov· March 2019

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Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy.
Ashley Orillion, Nur P Damayanti, Li Shen, Remi Adelaiye-Ogala, Hayley Affronti

Clin Cancer Res· December 2018

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Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Anna Bianchi-Smiraglia, Archis Bagati, Emily E Fink, Hayley C Affronti, Brittany C Lipchick

J Clin Invest· October 2018

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Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.
Hayley C Affronti, Mark D Long, Spencer R Rosario, Bryan M Gillard, Ellen Karasik

Oncotarget· November 2017

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Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.
Anna Bianchi-Smiraglia, Mitra S Rana, Colleen E Foley, Leslie M Paul, Brittany C Lipchick, Hayley C Affronti

Nat Methods· October 2017

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Metastatic phenotype in CWR22 prostate cancer xenograft following castration.
Steven J Seedhouse, Hayley C Affronti, Ellen Karasik, Bryan M Gillard, Gissou Azabdaftari

Prostate· March 2016

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The essential role of methylthioadenosine phosphorylase in prostate cancer.
Gaia Bistulfi, Hayley C Affronti, Barbara A Foster, Ellen Karasik, Bryan Gillard

Oncotarget· March 2016

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