Publications by authors named "Heather M Stringham"

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Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits.
Emma P Wilson, K Alaine Broadaway, Victoria A Parsons, Swarooparani Vadlamudi, Narisu Narisu, Heather M Stringham

Am J Hum Genet· November 2025

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Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell type abundance and fiber-type-level gene expression.
Dan L Ciotlos, Sarah C Hanks, Arushi Varshney, Michael R Erdos, Nandini Manickam, Heather M Stringham

bioRxiv· November 2025

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Extensive differential gene expression and regulation by sex in human skeletal muscle.
Sarah C Hanks, Abigail S Mauger, Arushi Varshney, Dan L Ciotlos, Nandini Manickam, Heather M Stringham

Cell Genom· August 2025

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Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints.
Xianyong Yin, Jack Li, Debraj Bose, Jeffrey Okamoto, Annie Kwon, Heather M Stringham

Nat Commun· March 2025

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Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.
Sarah M Brotman, Julia S El-Sayed Moustafa, Li Guan, K Alaine Broadaway, Dongmeng Wang, Heather M Stringham

Nat Genet· January 2025

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Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation.
Arushi Varshney, Nandini Manickam, Peter Orchard, Adelaide Tovar, Christa Ventresca, Heather M Stringham

bioRxiv· December 2024

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Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits.
Sarah M Brotman, Anniina Oravilahti, Jonathan D Rosen, Marcus Alvarez, Sini Heinonen, Heather M Stringham

Diabetes· November 2023

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Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.
Sarah M Brotman, Julia S El-Sayed Moustafa, Li Guan, K Alaine Broadaway, Dongmeng Wang, Heather M Stringham

bioRxiv· October 2023

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Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.
Sara M Willems, Natasha H J Ng, Juan Fernandez, Rebecca S Fine, Eleanor Wheeler, Heather M Stringham

Wellcome Open Res· October 2023

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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Vasiliki Lagou, Longda Jiang, Anna Ulrich, Liudmila Zudina, Karla Sofia Gutiérrez González, Heather M Stringham

Nat Genet· September 2023

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Metabolome-wide Mendelian randomization characterizes heterogeneous and shared causal effects of metabolites on human health.
Xianyong Yin, Jack Li, Debraj Bose, Jeffrey Okamoto, Annie Kwon, Heather M Stringham

medRxiv· June 2023

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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Heather M Stringham

Genome Biol· December 2022

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Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.
Xianyong Yin, Debraj Bose, Annie Kwon, Sarah C Hanks, Anne U Jackson, Heather M Stringham

Am J Hum Genet· October 2022

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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Heather M Stringham

Kidney Int· September 2022

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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
Zhe Wang, Andrew Emmerich, Nicolas J Pillon, Tim Moore, Daiane Hemerich, Heather M Stringham

Nat Genet· September 2022

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ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.
Julia S El-Sayed Moustafa, Anne U Jackson, Sarah M Brotman, Li Guan, Sergio Villicaña, Heather M Stringham

Int J Obes (Lond)· August 2022

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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Thomas W Winkler, Humaira Rasheed, Alexander Teumer, Mathias Gorski, Bryce X Rowan, Heather M Stringham

Commun Biol· June 2022

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Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.
Xianyong Yin, Lap Sum Chan, Debraj Bose, Anne U Jackson, Peter VandeHaar, Heather M Stringham

Nat Commun· March 2022

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The trans-ancestral genomic architecture of glycemic traits.
Ji Chen, Cassandra N Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J Corbin, Heather M Stringham

Nat Genet· June 2021

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Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.
Cassandra N Spracklen, Apoorva K Iyengar, Swarooparani Vadlamudi, Chelsea K Raulerson, Anne U Jackson, Heather M Stringham

PLoS Genet· September 2020

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ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.
Julia S El-Sayed Moustafa, Anne U Jackson, Sarah M Brotman, Li Guan, Sergio Villicaña, Heather M Stringham

medRxiv· August 2020

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Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.
Ying Wu, K Alaine Broadaway, Chelsea K Raulerson, Laura J Scott, Calvin Pan, Heather M Stringham

Hum Mol Genet· December 2019

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Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power.
Adam E Locke, Karyn Meltz Steinberg, Charleston W K Chiang, Susan K Service, Aki S Havulinna, Heather M Stringham

Nature· November 2019

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Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits.
Chelsea K Raulerson, Arthur Ko, John C Kidd, Kevin W Currin, Sarah M Brotman, Heather M Stringham

Am J Hum Genet· October 2019

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Exome sequencing of Finnish isolates enhances rare-variant association power.
Adam E Locke, Karyn Meltz Steinberg, Charleston W K Chiang, Susan K Service, Aki S Havulinna, Heather M Stringham

Nature· August 2019

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