Publications by authors named "Heather Wheeler"

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Brain Transcriptome-wide Association Studies in Diverse Ancestral Populations Reveal Genes Implicated in an Anxiety-Related Phenotype.
Maya Z Sharma, Heather E Wheeler

G3 (Bethesda)· November 2025

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Comparison of associations suggests mainly distinct pools of genetic risk factors contribute to cisplatin-induced hearing loss and hearing difficulty in the general population.
Mohammad Shahbazi, Heather E Wheeler, Xindi Zhang, Robert D Frisina, Lois B Travis

Front Pharmacol· September 2025

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BDNF/BDNF-AS Gene Polymorphisms Modulate Treatment Response and Remission in Bipolar Disorder: A Randomized Clinical Trial.
Anton Shkundin, Heather E Wheeler, James Sinacore, Angelos Halaris

J Pers Med· February 2025

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Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed.
Peter Orchard, Thomas W Blackwell, Linda Kachuri, Peter J Castaldi, Michael H Cho, Heather E Wheeler

medRxiv· February 2025

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Comparison of GWAS results between de novo tinnitus and cancer treatment-related tinnitus suggests distinctive roles for genetic risk factors.
Mohammad Shahbazi, Heather E Wheeler, Gregory T Armstrong, Robert D Frisina, Lois B Travis

Sci Rep· November 2024

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Type I interferon regulation by USP18 is a key vulnerability in cancer.
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R Healy, Kymberly Levine

iScience· April 2024

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Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.
Henry Wittich, Kristin Ardlie, Kent D Taylor, Peter Durda, Yongmei Liu, Heather E Wheeler

Am J Hum Genet· March 2024

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Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations.
Daniel S Araujo, Chris Nguyen, Xiaowei Hu, Anna V Mikhaylova, Chris Gignoux, Heather E Wheeler

HGG Adv· October 2023

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Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.
Isabelle Gregga, Paul D P Pharoah, Simon A Gayther, Ani Manichaikul, Hae Kyung Im, Heather E Wheeler

Cancer Epidemiol Biomarkers Prev· September 2023

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Multivariate adaptive shrinkage improves cross-population transcriptome prediction for transcriptome-wide association studies in underrepresented populations.
Daniel S Araujo, Chris Nguyen, Xiaowei Hu, Anna V Mikhaylova, Chris Gignoux, Heather E Wheeler

bioRxiv· May 2023

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Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.
Kangcheng Hou, Yi Ding, Ziqi Xu, Yue Wu, Arjun Bhattacharya, Heather E Wheeler

Nat Genet· April 2023

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Genetic and environmental variation impact transferability of polygenic risk scores.
Daniel S Araújo, Heather E Wheeler

Cell Rep Med· July 2022

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Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.
Xiaowei Hu, Dandi Qiao, Wonji Kim, Matthew Moll, Pallavi P Balte, Heather E Wheeler

Am J Hum Genet· May 2022

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Protein prediction for trait mapping in diverse populations.
Ryan Schubert, Elyse Geoffroy, Isabelle Gregga, Ashley J Mulford, Francois Aguet, Heather E Wheeler

PLoS One· March 2022

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Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries.
Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A Palmer, Nancy J Cox, Heather E Wheeler

Genome Biol· January 2022

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Clinical and genetic risk factors for radiation-associated ototoxicity: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.
Matthew R Trendowski, Jessica L Baedke, Yadav Sapkota, Lois B Travis, Xindi Zhang, Heather E Wheeler

Cancer· November 2021

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Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response.
Aaron Y Chang, Yu Jerry Zhou, Sharanya Iyengar, Piotr W Pobiarzyn, Pavel Tishchenko, Heather Wheeler

J Biol Chem· November 2021

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Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations.
Ashley J Mulford, Claudia Wing, M Eileen Dolan, Heather E Wheeler

Hum Mol Genet· April 2021

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Transcriptome prediction performance across machine learning models and diverse ancestries.
Paul C Okoro, Ryan Schubert, Xiuqing Guo, W Craig Johnson, Jerome I Rotter, Heather E Wheeler

HGG Adv· April 2021

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Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.
Matthew R Trendowski, Heather E Wheeler, Omar El-Charif, Darren R Feldman, Robert J Hamilton

Clin Cancer Res· December 2020

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Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate.
Elyse Geoffroy, Isabelle Gregga, Heather E Wheeler

iScience· December 2020

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Multi-ethnic transcriptome-wide association study of prostate cancer.
Peter N Fiorica, Ryan Schubert, John D Morris, Mohammed Abdul Sami, Heather E Wheeler

PLoS One· October 2020

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Comparing local ancestry inference models in populations of two- and three-way admixture.
Ryan Schubert, Angela Andaleon, Heather E Wheeler

PeerJ· October 2020

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Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification.
Alvaro N Barbeira, Owen J Melia, Yanyu Liang, Rodrigo Bonazzola, Gao Wang, Heather E Wheeler

Genet Epidemiol· September 2020

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Genetic regulatory variation in populations informs transcriptome analysis in rare disease.
Pejman Mohammadi, Stephane E Castel, Beryl B Cummings, Jonah Einson, Christina Sousa, Heather E Wheeler

Science· October 2019

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