Publications by authors named "Hector Esquer"

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Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance.
Marika L Klosowski, Kathryn E Cronise, Eric P Palmer, Kelly McAuliffe, Claire Stratton, Hector Esquer

Proc Natl Acad Sci U S A· November 2025

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CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential.
Sophia Clune, Paul Awolade, Hector Esquer, Qiong Zhou, Daniel V LaBarbera

J Exp Clin Cancer Res· May 2025

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Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer.
Hector Esquer, Qiong Zhou, Daniel V LaBarbera

Cells· February 2025

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CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models.
Rita Sala, Hector Esquer, Timothy Kellett, Sophia Clune, Paul Awolade

Int J Mol Sci· December 2024

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CHD1L Regulates Cell Survival in Breast Cancer and Its Inhibition by OTI-611 Impedes the DNA Damage Response and Induces PARthanatos.
Rita Sala, Hector Esquer, Timothy Kellett, Jeffrey T Kearns, Paul Awolade

Int J Mol Sci· August 2024

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The validation of new CHD1L inhibitors as a therapeutic strategy for cancer.
Sophia Clune, Paul Awolade, Qiong Zhou, Hector Esquer, Brock Matter

Biomed Pharmacother· January 2024

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HTS discovery of PARP1-HPF1 complex inhibitors in cancer.
Timothy Kellett, Rida Noor, Qiong Zhou, Hector Esquer, Rita Sala

SLAS Discov· December 2023

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High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes.
Sébastien Rinaldetti, Qiong Zhou, Joshua M Abbott, Florus C de Jong, Hector Esquer

Int J Mol Sci· September 2022

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Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Kendra M Prutton, John O Marentette, Brice A Leifheit, Hector Esquer, Daniel V LaBarbera

Free Radic Biol Med· June 2022

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Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L.
Brett J Prigaro, Hector Esquer, Qiong Zhou, Laura A Pike, Paul Awolade

J Med Chem· March 2022

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Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer.
Hector Esquer, Qiong Zhou, Travis Nemkov, Adedoyin D Abraham, Sébastien Rinaldetti

Oncogene· April 2021

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Advanced High-Content-Screening Applications of Clonogenicity in Cancer.
Hector Esquer, Qiong Zhou, Adedoyin D Abraham, Daniel V LaBarbera

SLAS Discov· August 2020

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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.
Joshua M Abbott, Qiong Zhou, Hector Esquer, Laura Pike, Travis P Broneske

Mol Cancer Ther· August 2020

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Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.
Adedoyin D Abraham, Hector Esquer, Qiong Zhou, Nicholas Tomlinson, Brayden D Hamill

J Med Chem· November 2019

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Mitochondrial-Localized Versus Cytosolic Intracellular CO-Releasing Organic PhotoCORMs: Evaluation of CO Effects Using Bioenergetics.
Livia S Lazarus, Hector J Esquer, Stacey N Anderson, Lisa M Berreau, Abby D Benninghoff

ACS Chem Biol· August 2018

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Sense and Release: A Thiol-Responsive Flavonol-Based Photonically Driven Carbon Monoxide-Releasing Molecule That Operates via a Multiple-Input AND Logic Gate.
Livia S Lazarus, Hector J Esquer, Abby D Benninghoff, Lisa M Berreau

J Am Chem Soc· July 2017

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A Structurally-Tunable 3-Hydroxyflavone Motif for Visible Light-Induced Carbon Monoxide-Releasing Molecules (CORMs).
Stacey N Anderson, Jason M Richards, Hector J Esquer, Abby D Benninghoff, Atta M Arif

ChemistryOpen· October 2015

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