Publications by authors named "Heike Keilhack"

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Identification of novel regulators of LINE-1 expression via CRISPR/Cas9 screening.
Ozgur Oksuz, Chong Chu, Cedric Arisdakessian, Liyang Diao, Dennis Zaller, Heike Keilhack

Mob DNA· December 2025

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Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.
Alex M Eddie, Kevin W Chen, Laurie B Schenkel, Kerren K Swinger, Jennifer R Molina, Heike Keilhack

Immunohorizons· July 2022

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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Joseph M Gozgit, Melissa M Vasbinder, Ryan P Abo, Kaiko Kunii, Kristy G Kuplast-Barr, Heike Keilhack

Cancer Cell· September 2021

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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Laurie B Schenkel, Jennifer R Molina, Kerren K Swinger, Ryan Abo, Danielle J Blackwell, Heike Keilhack

Cell Chem Biol· August 2021

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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Tim J Wigle, Yue Ren, Jennifer R Molina, Danielle J Blackwell, Laurie B Schenkel, Heike Keilhack

Chembiochem· June 2021

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In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Tim J Wigle, Danielle J Blackwell, Laurie B Schenkel, Yue Ren, W David Church, Heike Keilhack

Cell Chem Biol· July 2020

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Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation.
Alvin Z Lu, Ryan Abo, Yue Ren, Bin Gui, Jan-Rung Mo, Heike Keilhack

Biochem Pharmacol· September 2019

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Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.
Antoine Italiano, Jean-Charles Soria, Maud Toulmonde, Jean-Marie Michot, Carlo Lucchesi, Heike Keilhack

Lancet Oncol· May 2018

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In Vitro Long-Term Proliferation Assays to Study Antiproliferative Effects of PARP Inhibitors on Cancer Cells.
Heike Keilhack, Paul Chang

Methods Mol Biol· April 2018

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EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming.
Remi Adelaiye-Ogala, Justin Budka, Nur P Damayanti, Justine Arrington, Mary Ferris, Heike Keilhack

Cancer Res· December 2017

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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL.
Dorothy Brach, Danielle Johnston-Blackwell, Allison Drew, Trupti Lingaraj, Vinny Motwani, Heike Keilhack

Mol Cancer Ther· November 2017

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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
Sarah K Knutson, Natalie M Warholic, L Danielle Johnston, Christine R Klaus, Tim J Wigle, Heike Keilhack

PLoS One· October 2017

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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Heike Keilhack

PLoS One· July 2017

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Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: and Preclinical Models.
Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R Grassian, Igor Feldman, Heike Keilhack

Mol Cancer Ther· May 2017

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Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program.
Raushan T Kurmasheva, Melissa Sammons, Edward Favours, Jianwrong Wu, Dias Kurmashev, Heike Keilhack

Pediatr Blood Cancer· March 2017

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Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Heike Keilhack

PLoS One· January 2017

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Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".
Lindsay M LaFave, Wendy Béguelin, Richard Koche, Matt Teater, Barbara Spitzer, Heike Keilhack

Nat Med· June 2016

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PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease.
Cigall Kadoch, Robert A Copeland, Heike Keilhack

Biochemistry· March 2016

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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat.
Kevin W Kuntz, John E Campbell, Heike Keilhack, Roy M Pollock, Sarah K Knutson

J Med Chem· February 2016

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Loss of BAP1 function leads to EZH2-dependent transformation.
Lindsay M LaFave, Wendy Béguelin, Richard Koche, Matt Teater, Barbara Spitzer, Heike Keilhack

Nat Med· November 2015

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Small molecule inhibitors of EZH2: the emerging translational landscape.
Heike Keilhack, Jesse J Smith

Epigenomics· September 2015

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EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
John E Campbell, Kevin W Kuntz, Sarah K Knutson, Natalie M Warholic, Heike Keilhack

ACS Med Chem Lett· May 2015

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Reaction coupling between wild-type and disease-associated mutant EZH2.
Brooke M Swalm, Sarah K Knutson, Natalie M Warholic, Lei Jin, Kevin W Kuntz, Heike Keilhack

ACS Chem Biol· November 2014

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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma.
Sarah K Knutson, Satoshi Kawano, Yukinori Minoshima, Natalie M Warholic, Kuan-Chun Huang, Heike Keilhack

Mol Cancer Ther· April 2014

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Sarah K Knutson, Natalie M Warholic, Tim J Wigle, Christine R Klaus, Christina J Allain, Heike Keilhack

Proc Natl Acad Sci U S A· May 2013

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