Publications by authors named "Helen Huls"

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Sleeping beauty generated CD19 CAR T-Cell therapy for advanced B-Cell hematological malignancies.
Harjeet Singh, Samer A Srour, Denái R Milton, Jessica McCarty, Cuiping Dai, Helen Huls

Front Immunol· December 2022

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Adoptive immunotherapy with double-bright (CD56 /CD16 ) expanded natural killer cells in patients with relapsed or refractory acute myeloid leukaemia: a proof-of-concept study.
Lucia Silla, Vanessa Valim, Annelise Pezzi, Maria da Silva, Ianae Wilke, Helen Huls

Br J Haematol· December 2021

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Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models.
Denise L Crossland, Warren L Denning, Sonny Ang, Simon Olivares, Tiejuan Mi, Helen Huls

Oncogene· July 2018

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Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors.
Radhika Thokala, Simon Olivares, Tiejuan Mi, Sourindra Maiti, Drew Deniger, Helen Huls

PLoS One· July 2017

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Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.
Amer M Najjar, Pallavi R Manuri, Simon Olivares, Leo Flores, Tiejuan Mi, Helen Huls

Mol Imaging Biol· December 2016

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Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.
Lenka V Hurton, Harjeet Singh, Amer M Najjar, Kirsten C Switzer, Tiejuan Mi, Helen Huls

Proc Natl Acad Sci U S A· November 2016

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Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.
Partow Kebriaei, Harjeet Singh, M Helen Huls, Matthew J Figliola, Roland Bassett

J Clin Invest· September 2016

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Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor.
Hillary G Caruso, Hiroki Torikai, Ling Zhang, Sourindra Maiti, Jianliang Dai, Helen Huls

J Immunother· June 2016

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Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations.
Drew C Deniger, Jianqiang Yu, M Helen Huls, Matthew J Figliola, Tiejuan Mi

PLoS One· April 2016

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Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application.
Hiroki Torikai, Tiejuan Mi, Loren Gragert, Martin Maiers, Amer Najjar, Helen Huls

Sci Rep· February 2016

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Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma.
Marie-Andrée Forget, Shruti Malu, Hui Liu, Christopher Toth, Sourindra Maiti, Helen Huls

J Immunother· November 2015

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Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System.
Pappanaicken Kumaresan, Mathew Figliola, Judy S Moyes, M Helen Huls, Priti Tewari

J Vis Exp· October 2015

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Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.
Hillary G Caruso, Lenka V Hurton, Amer Najjar, David Rushworth, Sonny Ang, Helen Huls

Cancer Res· September 2015

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Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma.
Janani Krishnamurthy, Brian A Rabinovich, Tiejuan Mi, Kirsten C Switzer, Simon Olivares, Helen M Huls

Clin Cancer Res· July 2015

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Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.
Ivan Liadi, Harjeet Singh, Gabrielle Romain, Nicolas Rey-Villamizar, Amine Merouane, Helen Huls

Cancer Immunol Res· May 2015

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Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies.
Drew C Deniger, Sourindra N Maiti, Tiejuan Mi, Kirsten C Switzer, Vijaya Ramachandran, M Helen Huls

Clin Cancer Res· November 2014

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Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
Pappanaicken R Kumaresan, Pallavi R Manuri, Nathaniel D Albert, Sourindra Maiti, Harjeet Singh, M Helen Huls

Proc Natl Acad Sci U S A· July 2014

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Driving CAR-based T-cell therapy to success.
Bipulendu Jena, Judy S Moyes, Helen Huls, Laurence J N Cooper

Curr Hematol Malig Rep· March 2014

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Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.
Parijat Bhatnagar, Mian Alauddin, James A Bankson, Dickson Kirui, Payam Seifi, Helen Huls

Sci Rep· March 2014

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Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells.
Harjeet Singh, Matthew J Figliola, Margaret J Dawson, Simon Olivares, Ling Zhang, Helen Huls

PLoS One· February 2014

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A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19.
Harjeet Singh, Helen Huls, Partow Kebriaei, Laurence J N Cooper

Immunol Rev· January 2014

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Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials.
Bipulendu Jena, Sourindra Maiti, Helen Huls, Harjeet Singh, Dean A Lee

PLoS One· August 2013

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Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
Hiroki Torikai, Andreas Reik, Frank Soldner, Edus H Warren, Carrie Yuen, Helen Huls

Blood· August 2013

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Sleeping beauty system to redirect T-cell specificity for human applications.
Sourindra N Maiti, Helen Huls, Harjeet Singh, Margaret Dawson, Matthew Figliola

J Immunother· February 2013

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Clinical application of Sleeping Beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood.
M Helen Huls, Matthew J Figliola, Margaret J Dawson, Simon Olivares, Partow Kebriaei

J Vis Exp· February 2013

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