Publications by authors named "Helen Small"

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Ben Acton, Helen F Small, Kate M Smith, Alison McGonagle, Alexandra I J Stowell

Bioorg Med Chem Lett· February 2019

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
Bohdan Waszkowycz, Kate M Smith, Alison E McGonagle, Allan M Jordan, Ben Acton, Helen F Small

J Med Chem· December 2018

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Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.
Daniel P Mould, Ulf Bremberg, Allan M Jordan, Matthis Geitmann, Alba Maiques-Diaz, Helen F Small

Bioorg Med Chem Lett· July 2017

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Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
Stuart Jones, Jonathan Ahmet, Kelly Ayton, Matthew Ball, Mark Cockerill, Helen Small

J Med Chem· December 2016

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
Dominic I James, Kate M Smith, Allan M Jordan, Emma E Fairweather, Louise A Griffiths, Helen Small

ACS Chem Biol· November 2016

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Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.
Charlotte Sefton, Erika Harno, Alison Davies, Helen Small, Tiffany-Jayne Allen

Endocrinology· November 2016

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Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
Amanda J Watson, Gemma V Hopkins, Samantha Hitchin, Habiba Begum, Stuart Jones, Helen Small

F1000Res· September 2016

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Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Allan M Jordan, Habiba Begum, Emma Fairweather, Samantha Fritzl, Kristin Goldberg, Helen F Small

Bioorg Med Chem Lett· June 2016

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The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Rebecca Newton, Katherine A Bowler, Emily M Burns, Philip J Chapman, Emma E Fairweather, Helen F Small

Eur J Med Chem· April 2016

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Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.
Daniel H Wiseman, Helen F Small, Deepti P Wilks, Ian D Waddell, Michael W Dennis

Br J Haematol· July 2014

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Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
Ali Raoof, Paul Depledge, Niall M Hamilton, Nicola S Hamilton, James R Hitchin, Helen F Small

J Med Chem· August 2013

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Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
Niall M Hamilton, Martin Dawson, Emma E Fairweather, Nicola S Hamilton, James R Hitchin, Helen F Small

J Med Chem· May 2012

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Measurement of binding of basic drugs to acidic phospholipids using surface plasmon resonance and incorporation of the data into mechanistic tissue composition equations to predict steady-state volume of distribution.
Helen Small, Iain Gardner, Hannah M Jones, John Davis, Malcolm Rowland

Drug Metab Dispos· October 2011

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