Publications by authors named "Helen Yu"

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Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.
Eda Canales, Winston Tse, Scott D Schroeder, Chien-Hung Chou, Qi Liu, Helen Yu

J Med Chem· October 2025

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Enhancing children's health literacy: a scoping review of resources for 'Curriculum for Wales' health and well-being design, implementation, and assessment.
Levi Hughes, Michaela James, Helen Lewis, Gisselle Tur Porres, Helen Yu

Health Promot Int· October 2025

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Maladaptive personality traits and older adult relationship satisfaction: A co-twin control approach to understanding associations.
Helen H Yu, Colin D Freilich, Sylia Wilson, Matt McGue, Glenn I Roisman

J Pers· April 2025

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Activating PKC-ε induces HIV expression with improved tolerability.
Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Helen Yu, Yu-San Yang

PLoS Pathog· February 2025

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Sarcopenia-related changes in serum GLP-1 level affect myogenic differentiation.
Hsien-Hao Huang, Yun-Jie Wang, Hui-Yu Jiang, Helen Wenshin Yu, Yin-Quan Chen

J Cachexia Sarcopenia Muscle· October 2024

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Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity.
Wan-Yu Chiang, Helen Wenshin Yu, Ming-Chung Wu, Yi-Man Huang, Yin-Quan Chen

Biomaterials· July 2024

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High-viscosity driven modulation of biomechanical properties of human mesenchymal stem cells promotes osteogenic lineage.
Yin-Quan Chen, Ming-Chung Wu, Ming-Tzo Wei, Jean-Cheng Kuo, Helen Wenshin Yu

Mater Today Bio· June 2024

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Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Andrew Mulato, Eric Lansdon, Ron Aoyama, Johannes Voigt, Michael Lee, Ruoyu Gong, Helen Yu

Antimicrob Agents Chemother· April 2024

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Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent.
Raju Subramanian, Jennifer Tang, Jim Zheng, Bing Lu, Kelly Wang, Helen Yu

Mol Pharm· December 2023

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Geometric Deep Learning for Structure-Based Ligand Design.
Alexander S Powers, Helen H Yu, Patricia Suriana, Rohan V Koodli, Tianyu Lu

ACS Cent Sci· December 2023

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Laparoscopic Management of Blunt Pancreatic Trauma in Adults and Pediatric Patients: A Systematic Review.
Barbara Catellani, Daniela Caracciolo, Paolo Magistri, Cristiano Guidetti, Nunzia Menduni, Helen Yu

Biomed Res Int· November 2023

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Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells.
Ming-Chung Wu, Helen Wenshin Yu, Yin-Quan Chen, Meng-Hsin Ou, Ricardo Serrano, Yu-Jui Fan

Acta Biomater· June 2023

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Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
Ladislav Prener, Ondřej Baszczyňski, Martin M Kaiser, Martin Dračínský, George Stepan, Yu-Jen Lee, Helen Yu

J Med Chem· February 2023

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Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.
Sheli R Radoshitzky, Patrick Iversen, Xianghan Lu, Jing Zou, Suzanne J F Kaptein, Ruoyu Gong, Helen Yu

Sci Rep· February 2023

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus.
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Helen Yu

PLoS One· December 2022

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Semi-Mechanistic PK/PD Modeling and Simulation of Irreversible BTK Inhibition to Support Dose Selection of Tirabrutinib in Subjects with RA.
Amy Meng, Rita Humeniuk, Juliane M Jürgensmeier, Chia-Hsiang Hsueh, Franziska Matzkies, Helen Yu

Clin Pharmacol Ther· February 2022

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Return of Benefit to Society of Publicly Funded Innovations to Combat COVID-19.
Helen Yu

Inquiry· December 2021

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Responsible use of negative research outcomes-accelerating the discovery and development of new antibiotics.
Helen Yu

J Antibiot (Tokyo)· September 2021

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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Richard L Mackman, Michael Mish, Gregory Chin, Jason K Perry, Todd Appleby, Peter Pyun, Helen Yu

J Med Chem· September 2020

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Clinical targeting of HIV capsid protein with a long-acting small molecule.
John O Link, Martin S Rhee, Winston C Tse, Jim Zheng, John R Somoza, Helen Yu

Nature· August 2020

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Leveraging Research Failures to Accelerate Drug Discovery and Development.
Helen Yu

Ther Innov Regul Sci· July 2020

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Cytopathological review of cervical pathology: Impact for women and follow-up results.
Simon M Scheck, Sam J Lepine, Helen Yu, Olivia Robb, Peter Fitzgerald

Aust N Z J Obstet Gynaecol· June 2020

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Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
Peter Blomgren, Jayaraman Chandrasekhar, Julie A Di Paolo, Wanchi Fung, Guoju Geng, Helen Yu

ACS Med Chem Lett· April 2020

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A potent nuclear export mechanism imposes USP16 cytoplasmic localization during interphase.
Nadine Sen Nkwe, Salima Daou, Maxime Uriarte, Jessica Gagnon, Nicholas Victor Iannantuono, Helen Yu

J Cell Sci· February 2020

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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.
Stephen R Yant, Andrew Mulato, Derek Hansen, Winston C Tse, Anita Niedziela-Majka, Helen Yu

Nat Med· September 2019

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