Publications by authors named "Eric Lansdon"

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A highly selective TCR-mimic antibody reveals unexpected mechanisms of HBV peptide-MHC recognition and previously unknown target biology.
Shahzada Khan, Jeremy Lum, Heather Stephenson, Pawan Bir Kohli, David Mortenson, Eric Lansdon

MAbs· December 2025

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Structural and mechanistic insights into herpesvirus helicase-primase and its therapeutic inhibitors.
Qing Yao, Alexandre Mercier, Arabinda Nayak, Lindsey May, Pui Yan Ho, Eric Lansdon

Nat Microbiol· December 2025

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A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription.
Jason K Perry, Samuel Itskanov, John P Bilello, Eric B Lansdon

J Virol· November 2025

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The therapeutic antibody sacituzumab induces trophoblast cell-surface antigen-2 conformational rearrangement.
Ryan Ferrao, Jinjin Zhang, Chih-Chien Chou, Anthony Nieto, Derek Langeslay, Eric B Lansdon

Structure· November 2025

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Discovery of Edecesertib (GS-5718): A Potent, Selective Inhibitor of IRAK4.
Stephen E Ammann, Jeromy J Cottell, Nathan E Wright, Matthew R Warr, Chelsea A Snyder, Eric B Lansdon

J Med Chem· June 2025

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Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Andrew Mulato, Eric Lansdon, Ron Aoyama, Johannes Voigt, Michael Lee

Antimicrob Agents Chemother· April 2024

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Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
Ladislav Prener, Ondřej Baszczyňski, Martin M Kaiser, Martin Dračínský, George Stepan, Eric B Lansdon

J Med Chem· February 2023

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Elucidating molecular interactions of -nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.
Magdeleine Hung, E John Tokarsky, Leanna Lagpacan, Lijun Zhang, Zucai Suo, Eric B Lansdon

Commun Biol· July 2020

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Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
Peter Blomgren, Jayaraman Chandrasekhar, Julie A Di Paolo, Wanchi Fung, Guoju Geng, Eric B Lansdon

ACS Med Chem Lett· April 2020

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Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
Julie Farand, Jeffrey E Kropf, Peter Blomgren, Jianjun Xu, Aaron C Schmitt, Eric B Lansdon

ACS Med Chem Lett· March 2020

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Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
David Sperandio, Vangelis Aktoudianakis, Kerim Babaoglu, Xiaowu Chen, Kristyna Elbel, Eric Lansdon

Bioorg Med Chem· February 2019

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ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
John T Liles, Britton K Corkey, Gregory T Notte, Grant R Budas, Eric B Lansdon

J Clin Invest· October 2018

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Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.
Petr Šimon, Ondřej Baszczyňski, David Šaman, George Stepan, Eric Hu, Eric B Lansdon

Eur J Med Chem· October 2016

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Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.
Kevin S Currie, Jeffrey E Kropf, Tony Lee, Peter Blomgren, Jianjun Xu, Eric B Lansdon

J Med Chem· May 2014

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Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Jay Parrish, Leah Tong, Michael Wang, Xiaowu Chen, Eric B Lansdon

Bioorg Med Chem Lett· March 2013

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New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
Manuel Tsiang, Gregg S Jones, Anita Niedziela-Majka, Elaine Kan, Eric B Lansdon

J Biol Chem· June 2012

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The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness.
Rima Kulkarni, Kerim Babaoglu, Eric B Lansdon, Laurence Rimsky, Veerle Van Eygen

J Acquir Immune Defic Syndr· January 2012

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Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.
Brian J Scarth, Kirsten L White, James M Chen, Eric B Lansdon, S Swaminathan

Antimicrob Agents Chemother· June 2011

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Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Eric B Lansdon, Qi Liu, Stephanie A Leavitt, Mini Balakrishnan, Jason K Perry

Antimicrob Agents Chemother· June 2011

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Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.
Eric B Lansdon, Katherine M Brendza, Magdeleine Hung, Ruth Wang, Susmith Mukund

J Med Chem· May 2010

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Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.
Eric B Lansdon, Dharmaraj Samuel, Leanna Lagpacan, Katherine M Brendza, Kirsten L White

J Mol Biol· April 2010

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N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Michael L Mitchell, Jong Chan Son, Ill Young Lee, Chong-Kyo Lee, Hae Soo Kim, Eric B Lansdon

Bioorg Med Chem Lett· March 2010

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N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Michael L Mitchell, Jong Chan Son, Hongyan Guo, Yun-A Im, Eun Jung Cho, Eric B Lansdon

Bioorg Med Chem Lett· March 2010

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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.
Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Susmith Mukund, Bin Han, Eric Lansdon

J Biol Chem· November 2009

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RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
Thorsten A Kirschberg, Mini Balakrishnan, Neil H Squires, Tiffany Barnes, Katherine M Brendza, Eric B Lansdon

J Med Chem· October 2009

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