Publications by authors named "Susmith Mukund"

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MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens.
Jan Andersson, Sanne Cowland, Mikkel Vestergaard, Yajing Yang, Siyuan Liu, Susmith Mukund

Proc Natl Acad Sci U S A· May 2025

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Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of -Deleted Cancers.
Liping H Pettus, Matthew Bourbeau, Nuria A Tamayo, Albert Amegadzie, Diane Beylkin, Susmith Mukund

J Med Chem· April 2025

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From DNA-Encoded Library Screening to : An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.
Ian Sarvary, Mikkel Vestergaard, Loris Moretti, Jan Andersson, Jorge Peiró Cadahía, Susmith Mukund

J Med Chem· March 2025

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AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers.
Brian Belmontes, Katherine K Slemmons, Chun Su, Siyuan Liu, Antonia N Policheni, Susmith Mukund

Cancer Discov· January 2025

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Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Aaron H Nile, Felipe de Sousa E Melo, Susmith Mukund, Robert Piskol, Simon Hansen

Nat Chem Biol· September 2018

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A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Aaron H Nile, Felipe de Sousa E Melo, Susmith Mukund, Robert Piskol, Simon Hansen

Nat Chem Biol· June 2018

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Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Aaron H Nile, Susmith Mukund, Karen Stanger, Weiru Wang, Rami N Hannoush

Proc Natl Acad Sci U S A· April 2017

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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.
Eugene Y Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Susmith Mukund

Nat Commun· March 2017

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Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Ingrid E Wertz, Kim Newton, Dhaya Seshasayee, Saritha Kusam, Cynthia Lam, Susmith Mukund

Nature· April 2016

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Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Ingrid E Wertz, Kim Newton, Dhaya Seshasayee, Saritha Kusam, Cynthia Lam, Susmith Mukund

Nature· December 2015

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Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Shivani Ahuja, Susmith Mukund, Lunbin Deng, Kuldip Khakh, Elaine Chang

Science· December 2015

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Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
Susmith Mukund, Yonglei Shang, Holly J Clarke, Azadeh Madjidi, Jacob E Corn

J Biol Chem· December 2013

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Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.
Benjamin E L Lauffer, Robert Mintzer, Rina Fong, Susmith Mukund, Christine Tam

J Biol Chem· September 2013

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Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
Anthony A Estrada, Xingrong Liu, Charles Baker-Glenn, Alan Beresford, Daniel J Burdick, Susmith Mukund

J Med Chem· November 2012

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Molecular basis for negative regulation of the glucagon receptor.
Christopher M Koth, Jeremy M Murray, Susmith Mukund, Azadeh Madjidi, Alexandra Minn

Proc Natl Acad Sci U S A· September 2012

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Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Dharmaraj Samuel, Nikolai Novikov, Susmith Mukund

Biochemistry· March 2011

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Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.
Eric B Lansdon, Katherine M Brendza, Magdeleine Hung, Ruth Wang, Susmith Mukund

J Med Chem· May 2010

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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.
Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Susmith Mukund, Bin Han

J Biol Chem· November 2009

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R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
Cristina V Iancu, Susmith Mukund, Herbert J Fromm, Richard B Honzatko

J Biol Chem· May 2005

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Amino terminus of Plasmodium falciparum acidic basic repeat antigen interacts with the erythrocyte membrane through band 3 protein.
Ashima Kushwaha, Ashiya Perween, Susmith Mukund, Suman Majumdar, Devesh Bhardwaj

Mol Biochem Parasitol· June 2002

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