Publications by authors named "Dharmaraj Samuel"

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Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.
Lauren K Ely, Marco Lolicato, Tovo David, Kate Lowe, Yun Cheol Kim, Dharmaraj Samuel

Structure· February 2018

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GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein.
Dharmaraj Samuel, Weimei Xing, Anita Niedziela-Majka, Jinny S Wong, Magdeleine Hung

Antimicrob Agents Chemother· November 2015

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Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.
John R Somoza, David Koditek, Armando G Villaseñor, Nikolai Novikov, Melanie H Wong, Dharmaraj Samuel

J Biol Chem· March 2015

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Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
Richard L Mackman, Michael Sangi, David Sperandio, Jay P Parrish, Eugene Eisenberg, Dharmaraj Samuel

J Med Chem· February 2015

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New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
Manuel Tsiang, Gregg S Jones, Anita Niedziela-Majka, Elaine Kan, Eric B Lansdon, Dharmaraj Samuel

J Biol Chem· June 2012

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A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.
Manuel Tsiang, Anita Niedziela-Majka, Magdeleine Hung, Debi Jin, Eric Hu, Dharmaraj Samuel

Biochemistry· June 2012

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Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Dharmaraj Samuel, Nikolai Novikov

Biochemistry· March 2011

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Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.
Eric B Lansdon, Dharmaraj Samuel, Leanna Lagpacan, Katherine M Brendza, Kirsten L White

J Mol Biol· April 2010

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Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation.
Dharmaraj Samuel, Hong Cheng, Paul W Riley, Adrian A Canutescu, Chandrasekaran Nagaswami

Proc Natl Acad Sci U S A· October 2007

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Dimer dissociation and unfolding mechanism of coagulation factor XI apple 4 domain: spectroscopic and mutational analysis.
Paul W Riley, Hong Cheng, Dharmaraj Samuel, Heinrich Roder, Peter N Walsh

J Mol Biol· March 2007

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Characterization and structural analyses of nonspecific lipid transfer protein 1 from mung bean.
Ku-Feng Lin, Yu-Nan Liu, Shang-Te D Hsu, Dharmaraj Samuel, Chao-Sheng Cheng

Biochemistry· April 2005

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Binding mechanism of nonspecific lipid transfer proteins and their role in plant defense.
Chao-Sheng Cheng, Dharmaraj Samuel, Yaw-Jen Liu, Je-Chyi Shyu, Szu-Ming Lai

Biochemistry· November 2004

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Mutagenesis study on the zebra fish SOX9 high-mobility group: comparison of sequence and non-sequence specific HMG domains.
Nai-Wan Hsiao, Dharmaraj Samuel, Yu-Nan Liu, Li-Chuan Chen, Tzu-Ying Yang

Biochemistry· September 2003

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Solution structure of plant nonspecific lipid transfer protein-2 from rice (Oryza sativa).
Dharmaraj Samuel, Yaw-Jen Liu, Chao-Sheng Cheng, Ping-Chiang Lyu

J Biol Chem· September 2002

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Purification and characterization of a novel 7-kDa non-specific lipid transfer protein-2 from rice (Oryza sativa).
Yaw-Jen Liu, Dharmaraj Samuel, Chi-Hung Lin, Ping-Chiang Lyu

Biochem Biophys Res Commun· June 2002

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