Publications by authors named "Debi Jin"

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A highly selective TCR-mimic antibody reveals unexpected mechanisms of HBV peptide-MHC recognition and previously unknown target biology.
Shahzada Khan, Jeremy Lum, Heather Stephenson, Pawan Bir Kohli, David Mortenson, Debi Jin

MAbs· December 2025

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The therapeutic antibody sacituzumab induces trophoblast cell-surface antigen-2 conformational rearrangement.
Ryan Ferrao, Jinjin Zhang, Chih-Chien Chou, Anthony Nieto, Derek Langeslay, Debi Jin

Structure· November 2025

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Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques.
Archana Vidya Boopathy, Anurag Nekkalapudi, Janette Sung, Sophie Schulha, Debi Jin

J Virol· July 2024

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Clinical targeting of HIV capsid protein with a long-acting small molecule.
John O Link, Martin S Rhee, Winston C Tse, Jim Zheng, John R Somoza, Debi Jin

Nature· August 2020

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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.
Stephen R Yant, Andrew Mulato, Derek Hansen, Winston C Tse, Anita Niedziela-Majka, Debi Jin

Nat Med· September 2019

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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi.
James G Taylor, Sheila Zipfel, Kyla Ramey, Randy Vivian, Adam Schrier, Yujin Wang, Debi Jin

Bioorg Med Chem Lett· August 2019

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Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
David Sperandio, Vangelis Aktoudianakis, Kerim Babaoglu, Xiaowu Chen, Kristyna Elbel, Jinfa Du, Debi Jin

Bioorg Med Chem· February 2019

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Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
Victoria A Steadman, Simon B Pettit, Karine G Poullennec, Linos Lazarides, Andrew J Keats, Debi Jin

J Med Chem· February 2017

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Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.
Latesh Lad, Sheila Clancy, David Koditek, Melanie H Wong, Debi Jin

Biochemistry· April 2015

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Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir.
Ona Barauskas, Amoreena C Corsa, Ruth Wang, Scott Hluhanich, Debi Jin

Biochim Biophys Acta· December 2014

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Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Joy Y Feng, Guofeng Cheng, Jason Perry, Ona Barauskas, Yili Xu, Debi Jin

Antimicrob Agents Chemother· November 2014

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Large-scale functional purification of recombinant HIV-1 capsid.
Magdeleine Hung, Anita Niedziela-Majka, Debi Jin, Melanie Wong, Stephanie Leavitt

PLoS One· December 2013

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Lipid-sensing high-throughput ApoA-I assays.
Anita Niedziela-Majka, Latesh Lad, Jeffrey W Chisholm, Leanna Lagpacan, Karen Schwartz, Debi Jin

J Biomol Screen· September 2012

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A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.
Manuel Tsiang, Anita Niedziela-Majka, Magdeleine Hung, Debi Jin, Eric Hu

Biochemistry· June 2012

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Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Dharmaraj Samuel, Nikolai Novikov, Debi Jin

Biochemistry· March 2011

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Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.
Eric B Lansdon, Katherine M Brendza, Magdeleine Hung, Ruth Wang, Susmith Mukund, Debi Jin

J Med Chem· May 2010

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