Publications by authors named "Jason Perry"

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A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription.
Jason K Perry, Samuel Itskanov, John P Bilello, Eric B Lansdon

J Virol· November 2025

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Endosome maturation during ER stress relies on the ubiquitin-binding domain of histone deacetylase 6.
Katherine M Piscopo, Brooke Larson, Anna M Christiansen, Jason M Perry, Julie Hollien

Mol Biol Cell· October 2025

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Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.
Eda Canales, Winston Tse, Scott D Schroeder, Chien-Hung Chou, Qi Liu, Jason K Perry

J Med Chem· October 2025

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Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys.
Jared Pitts, J Lizbeth Reyes Zamora, Savrina Manhas, Thomas Aeschbacher, Josolyn Chan, Jason K Perry

Nat Commun· July 2025

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Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir.
Derek Hansen, Matthew R Hendricks, Silvia Chang, Arthur Cai, Jason K Perry

mBio· May 2025

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SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants.
Lauren Rodriguez, Hery W Lee, Jiani Li, Ross Martin, Dong Han, Jason K Perry

Antimicrob Agents Chemother· February 2025

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Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations.
Sally Demirdjian, Vincent N Duong, Jennifer N Byrum, Arabinda Nayak, Cooper B McKinney, Jason K Perry

Microbiol Spectr· January 2025

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Remdesivir and Obeldesivir Retain Potent Antiviral Activity Against SARS-CoV-2 Omicron Variants.
Lauren Rodriguez, J Lizbeth Reyes Zamora, Dong Han, Jasmine Moshiri, Nadine Peinovich, Jason K Perry

Viruses· January 2025

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Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses.
Calvin J Gordon, Simon M Walker, Egor P Tchesnokov, Dana Kocincova, Jared Pitts, Jason K Perry

J Biol Chem· August 2024

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Discovery of GS-7682, a Novel 4'-Cyano-Modified -Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Dustin S Siegel, Hon C Hui, Jared Pitts, Meghan S Vermillion, Kazuya Ishida, Jason K Perry

J Med Chem· August 2024

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Safety, tolerability, and pharmacokinetics of a single orally inhaled dose of PUR3100, a dry powder formulation of dihydroergotamine versus intravenous dihydroergotamine: A Phase 1 randomized, double-blind study in healthy adults.
Susan Bodie, Aidan K Curran, Aaron C Gonzalez-Nelson, Jason M Perry, Debora C Manning

Headache· June 2024

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The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart, Jason K Perry

Sci Transl Med· May 2024

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Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.
Sarah Schmidt, Meron Mengistu, Stephane Daffis, Sarah Ahmadi-Erber, Daniela Deutschmann, Jason Perry

J Infect Dis· April 2024

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No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials.
Charlotte Hedskog, Christoph D Spinner, Ulrike Protzer, Dieter Hoffmann, Chunkyu Ko, Jason K Perry

Viruses· March 2024

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Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1).
Charlotte Hedskog, Lauren Rodriguez, Pavitra Roychoudhury, Meei-Li Huang, Keith R Jerome, Jason K Perry

J Infect Dis· November 2023

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Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential.
David R Martinez, Fernando R Moreira, Mark R Zweigart, Kendra L Gully, Gabriela De la Cruz, Jason Perry

bioRxiv· June 2023

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Structural basis for substrate selection by the SARS-CoV-2 replicase.
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen

Nature· February 2023

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Laura J Stevens, Andrea J Pruijssers, Hery W Lee, Calvin J Gordon, Egor P Tchesnokov, Jason K Perry

Sci Transl Med· August 2022

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Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.
Liva Checkmahomed, Julie Carbonneau, Venice Du Pont, Nicholas C Riola, Jason K Perry

Antimicrob Agents Chemother· July 2022

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Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Jared Pitts, Jiani Li, Jason K Perry, Venice Du Pont, Nicholas Riola

Antimicrob Agents Chemother· June 2022

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The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2.
Joy Y Feng, Venice Du Pont, Darius Babusis, Calvin J Gordon, Egor P Tchesnokov, Jason K Perry

Molecules· June 2022

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Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
James Chen, Qi Wang, Brandon Malone, Eliza Llewellyn, Yakov Pechersky, Jason K Perry

Nat Struct Mol Biol· March 2022

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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir.
Calvin J Gordon, Hery W Lee, Egor P Tchesnokov, Jason K Perry, Joy Y Feng

J Biol Chem· February 2022

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An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15.
Jason K Perry, Todd C Appleby, John P Bilello, Joy Y Feng, Uli Schmitz

J Biol Chem· October 2021

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Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
Egor P Tchesnokov, Calvin J Gordon, Emma Woolner, Dana Kocincova, Jason K Perry

J Biol Chem· August 2021

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