Publications by authors named "Helena Cirule"

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Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver.
Edgars Liepinsh, Liga Zvejniece, Laura Clemensson, Melita Ozola, Edijs Vavers, Helena Cirule

Br J Pharmacol· August 2024

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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Douglas L Huseby, Sha Cao, Edouard Zamaratski, Sanjeewani Sooriyaarachchi, Shabbir Ahmad, Helena Cirule

Proc Natl Acad Sci U S A· April 2024

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Innovative Approach to Enhance Bioavailability of Birch Bark Extracts: Novel Method of Oleogel Development Contrasted with Other Dispersed Systems.
Laura Andze, Sanita Vitolina, Rudolfs Berzins, Janis Rizikovs, Daniela Godina, Helena Cirule

Plants (Basel)· January 2024

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Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats.
Janis Kuka, Marina Makrecka-Kuka, Karlis Vilks, Stanislava Korzh, Helena Cirule

Oxid Med Cell Longev· January 2022

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Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
Reinis Vilskersts, Dana Kigitovica, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule

Int J Mol Sci· December 2021

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Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure.
Melita Videja, Reinis Vilskersts, Stanislava Korzh, Helena Cirule, Eduards Sevostjanovs

Front Cell Dev Biol· January 2021

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Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload.
Marina Makrecka-Kuka, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule

Cardiovasc Drugs Ther· December 2020

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Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury.
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova-Malkova

Physiol Rep· November 2020

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Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.
Marina Makrecka-Kuka, Stanislava Korzh, Karlis Vilks, Reinis Vilskersts, Helena Cirule

Shock· December 2019

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Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB.
Janis Kuka, Marina Makrecka-Kuka, Helena Cirule, Solveiga Grinberga, Eduards Sevostjanovs

Basic Clin Pharmacol Toxicol· August 2017

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Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.
Edgars Liepinsh, Elina Makarova, Eduards Sevostjanovs, Dace Hartmane, Helena Cirule

Basic Clin Pharmacol Toxicol· May 2017

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Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
Reinis Vilskersts, Janis Kuka, Edgars Liepinsh, Marina Makrecka-Kuka, Kristine Volska, Helena Cirule

Vascul Pharmacol· September 2015

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Magnesium nitrate attenuates blood pressure rise in SHR rats.
Reinis Vilskersts, Janis Kuka, Edgars Liepinsh, Helena Cirule, Anita Gulbe

Magnes Res· February 2015

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Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study.
Elina Makarova, Paweł Górnaś, Ilze Konrade, Dace Tirzite, Helena Cirule

J Sci Food Agric· February 2015

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Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.
Janis Kuka, Edgars Liepinsh, Marina Makrecka-Kuka, Janis Liepins, Helena Cirule

Life Sci· November 2014

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Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria.
Marina Makrecka, Janis Kuka, Kristine Volska, Unigunde Antone, Eduards Sevostjanovs, Helena Cirule

Mol Cell Biochem· October 2014

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Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
Edgars Liepinsh, Marina Makrecka, Janis Kuka, Helena Cirule, Elina Makarova

Pharmacol Res· July 2014

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Libiguins A and B: novel phragmalin limonoids isolated from Neobeguea mahafalensis causing profound enhancement of sexual activity.
Solofoniaina Razafimahefa, Felikss Mutulis, Ilze Mutule, Edvards Liepinsh, Maija Dambrova, Helena Cirule

Planta Med· March 2014

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The heart is better protected against myocardial infarction in the fed state compared to the fasted state.
Edgars Liepinsh, Marina Makrecka, Janis Kuka, Elina Makarova, Reinis Vilskersts, Helena Cirule

Metabolism· January 2014

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Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.
Reinis Vilskersts, Olga Zharkova-Malkova, Rudolfs Mezhapuke, Solveiga Grinberga, Helena Cirule

Clin Exp Pharmacol Physiol· August 2013

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Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
Edgars Liepinsh, Elina Skapare, Janis Kuka, Marina Makrecka, Helena Cirule

Naunyn Schmiedebergs Arch Pharmacol· June 2013

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The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
Janis Kuka, Reinis Vilskersts, Helena Cirule, Marina Makrecka, Osvalds Pugovics

J Cardiovasc Pharmacol Ther· June 2012

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Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
Reinis Vilskersts, Janis Kuka, Baiba Svalbe, Helena Cirule, Edgars Liepinsh

Pharmacol Rep· December 2011

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Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.
Edgars Liepinsh, Elina Skapare, Baiba Svalbe, Marina Makrecka, Helena Cirule

Eur J Pharmacol· May 2011

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Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Edgars Liepinsh, Janis Kuka, Baiba Svalbe, Reinis Vilskersts, Elina Skapare, Helena Cirule

Basic Clin Pharmacol Toxicol· December 2009

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