Publications by authors named "Helene Bazin"

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Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responses.
Fatemeh Mehradnia, Hardik Amin, Maria E Ferrini, Haley Partlow, Timothy Borgogna, Hélène G Bazin

Drug Deliv Transl Res· July 2025

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Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses.
Walid M Abdelwahab, Sarah Auclair, Timothy Borgogna, Karthik Siram, Alexander Riffey, Hélène G Bazin

Pharmaceutics· January 2024

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A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice.
Shannon M Miller, Bethany Crouse, Linda Hicks, Hardik Amin, Shelby Cole, Helene G Bazin

NPJ Vaccines· July 2023

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Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination.
David J Dowling, Soumik Barman, Alyson J Smith, Francesco Borriello, Danielle Chaney, Hélène G Bazin

Sci Rep· October 2022

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Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice.
Shannon M Miller, Van Cybulski, Margaret Whitacre, Laura S Bess, Mark T Livesay, Hélène G Bazin

Front Immunol· March 2021

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Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.
Hélène G Bazin, Laura S Bess, Mark T Livesay, Yufeng Li, Van Cybulski

Bioorg Med Chem Lett· March 2020

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Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity.
Kristopher K Short, Shannon M Miller, Lois Walsh, Van Cybulski, Hélène Bazin

J Control Release· December 2019

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Synthetic Toll-like Receptors 7 and 8 Agonists: Structure-Activity Relationship in the Oxoadenine Series.
Jay T Evans, Laura S Bess, Sandra C Mwakwari, Mark T Livesay, Yufeng Li, Hélène G Bazin

ACS Omega· September 2019

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Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants.
Alyson J Smith, Yufeng Li, Hélène G Bazin, Julien R St-Jean, Daniel Larocque

Vaccine· August 2016

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Phospholipidation of TLR7/8-active imidazoquinolines using a tandem phosphoramidite method.
Hélène G Bazin, Laura S Bess, Mark T Livesay, Sandra C Mwakwari, David A Johnson

Tetrahedron Lett· May 2016

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Efficient tin-mediated synthesis of lysophospholipid conjugates of a TLR7/8-active imidazoquinoline.
Sandra C Mwakwari, Laura S Bess, Hélène G Bazin, David A Johnson

Tetrahedron Lett· May 2016

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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives.
Hélène G Bazin, Yufeng Li, Juhienah K Khalaf, Sandra Mwakwari, Mark T Livesay

Bioorg Med Chem Lett· March 2015

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Characterization of TRIF selectivity in the AGP class of lipid A mimetics: role of secondary lipid chains.
Juhienah K Khalaf, William S Bowen, Hélène G Bazin, Kendal T Ryter, Mark T Livesay

Bioorg Med Chem Lett· February 2015

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The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics.
Hélène G Bazin, Tim J Murray, William S Bowen, Afsaneh Mozaffarian, Steven P Fling

Bioorg Med Chem Lett· October 2008

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The relation between p70S6k expression in lymphocytes and the decline of cognitive test scores in patients with Alzheimer disease.
Marc Paccalin, Stéphanie Pain-Barc, Claudette Pluchon, Chloé Paul, Hélène Bazin

Arch Intern Med· November 2005

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Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides.
Hélène G Bazin, Marcos A Marques, Albert P Owens, Robert J Linhardt, Keith A Crutcher

Biochemistry· June 2002

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Regio- and Stereoselective Synthesis of beta-D-Gluco-, alpha-L-Ido-, and alpha-L-Altropyranosiduronic Acids from Delta(4)-Uronates.
Hélène G. Bazin, Michael W. Wolff, Robert J. Linhardt

J Org Chem· January 1999

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